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My CartCAS：102-65-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow Solid
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| CAS | 102-65-8 |
| Name | Sulfaclozine |
| Molecular Formula | C10H9ClN4O2S |
| Molecular Weight | 284.72 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 203-044-0 |
| MDL | MFCD00868569 |
| SMILES | O=S(C1=CC=C(N)C=C1)(NC2=NC(Cl)=CN=C2)=O |
| InChIKey | QKLPUVXBJHRFQZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H9ClN4O2S/c11-9-5-13-6-10(14-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15) |
| PubChem CID | 66890 |
| Target Point | Antibiotic |
| Passage | Anti-infection |
| Background | Sulfaclozine is a potent sulfonamide derivative with antibacterial and anticoccidial effects. |
| Biological Activity | Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly， collibacteriosis， fowl cholera and coccidiosis)[1]. |
| In Vitro | The elimination of Sulfaclozine in the three systems: UV/TiO2，UV/K2S2O8，and UV/TiO2/K2S2O8. Sulfaclozine is weakly adsorbed on the surface of TiO2 at pH 7(< 5%)but efficiently eliminated with the following three systems: UV/TiO2，UV/K2S2O8，and UV/TiO2/K2S2O8 in ultra pure water. Moreover，12 of Sulfaclozine by-products are identified and reaction pathways show that，in addition of OH and SO4 radicals，the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals[2]. |
| In Vivo | Sulfaclozine(60 mg/kg; intravenous injection or oral administration; male broiler chickens)can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections[1]. |
| Data Literature Source | [1]. Sentepe I，et al. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010 Jan;48(1):448-451. [2]. Ismail L，et al. Effect of water constituents on the degradation of sulfaclozine in the three systems: UV/TiO2，UV/K2S2O8，and UV/TiO2/K2S2O8. Environ Sci Pollut Res Int. 2018 Jan;25(3):2651-2663. |
| Unit | Bottle |
| Specification | 20mg 100mg |
Sulfaclozine是一种有效的磺胺衍生物， 具有抗菌和抗球虫效果。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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