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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > AzaperoneCAS：1649-18-9
Molecular Formula：C19H22FN3O
Molecular Weight：327.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1649-18-9 |
| Name | Azaperone |
| Molecular Formula | C19H22FN3O |
| Molecular Weight | 327.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 216-715-8 |
| MDL | MFCD00866692 |
| SMILES | O=C(C1=CC=C(F)C=C1)CCCN2CCN(C3=NC=CC=C3)CC2 |
| InChIKey | XTKDAFGWCDAMPY-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2 |
| PubChem CID | 15443 |
| Target Point | Dopamine Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Azaperone is a dopamine antagonist with some antihistamine and anticholinergic properties. |
| Biological Activity | Azaperone (NSC 170976) 是一种吡啶哌嗪和丁酰苯类抗精神病药，具有镇静和止吐的效果，主要是在兽医上用作镇静剂。它是Dopamine receptors的拮抗剂，能够透过血脑屏障，结合D1和D2受体。[1-6] |
| In Vivo | Azaperone给药后仅几个小时会减少好斗行为，之后，经它处理过的猪的行为与不平静的混合的猪没有不同。[1] Azaperone(2.2 mg/kg i.m.)减少猪总体好斗行为，与生理盐水处理过的相比，从309.8 min下降到189.6 min。[2] Azaperone(103.1 mg)与Butorphanol(69.3 mg)结合使用，在患有慢性肾病的白色犀牛体内，会产生充分的肌肉松弛作用，且在小型外科干扰中，包括腹腔镜检查，具有明显的镇痛作用。[3] Azaperone结合Butorphanol和Medetomidine(BAM: 0.43 毫克/千克 Butorphanol，0.36 毫克/千克 Azaperone，0.14 毫克/千克Medetomidine)会引起可预测的镇静作用，在白尾鹿中平均诱发时间为9.8min。Azaperone结合Butorphanol和Medetomidine(BAM: 0.43 毫克/千克 Butorphanol，0.36 毫克/千克 Azaperone，0.14 毫克/千克Medetomidine)会导致白尾鹿心率下降，而动脉二氧化碳分压增加(PaCO2)。[4] Azaperone(1.0 mg/kg)与Ketamine(15 mg/kg)以及Climazolam(1.5 mg/kg)联合使用会引起一个显著的更高的去雄得分，小猪鼻内(IN)给药与肌内(IM)给药相比，在IN组，去雄得分与室温相关。Azaperone(1.0 mg/kg)与Ketamine(15 mg/kg)以及Climazolam(1.5 mg/kg)结合使用，会引起IN组小猪更高的心率。Azaperone(1.0 mg/kg)与Ketamine(15 mg/kg)以及Climazolam(1.5 mg/kg)结合使用，会导致IM组小猪更高的呼吸率，并且走路明显加快。[5] |
| Data Literature Source | [1] SSL Tan，et al. Appl Anim Behav Sci，1990，26(1-2)，157-168. [2] Gonyou HW，et al. J Anim Sci，1988，66(11)，2856-2864. [3] Radcliffe RW，et al. J Zoo Wildl Med，2000，31(2)，196-200. [4] Mich PM，et al. J Zoo Wildl Med，2008，39(3)，480-487. [5] Axiak SM，et al. Schweiz Arch Tierheilkd，2007，149(9)，395-402. [6] Sanhouri AA，et al. J Vet Pharmacol Ther. 1992，15(1):107-11. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
是一种多巴胺拮抗剂，具有一些抗组胺和抗胆碱特性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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