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Anti-Cleaved PARP Monoclonal Antibody

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Cat.No：K000215M Solarbio

Reactivity：Human

Application： WB,IHC

Storage：Store at -20℃. Avoid freeze/thaw cycles.

Host：Mouse

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Product Information

Name	Anti-Cleaved PARP Monoclonal Antibody
Host	Mouse
Clone Type	Monoclonal Antibody
Subtype	IgG1
Clone Number	Mix
Dilution Ratio	WB 1:2000-5000. IHC 1:200-500.
Target	Cleaved PARP
Background	Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.
Swiss Prot	P09874
Gene ID	142
Subcellular Location	Nucleus nucleolus
Immunogen	Synthetic Peptide
Calculated MW	116/89kDa
Purification Method	Saturated ammonium sulfate precipitation
Storage Buffer	PBS with 0.02% sodium azide，50% glycerol，pH7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Human
Application	WB IHC

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Kindly reminder：Quick spin before use. If you have any questions, please contact us.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.