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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > CytisineCAS：485-35-8
Molecular Formula：C11H14N2O
Molecular Weight：190.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 485-35-8 |
| Name | Cytisine |
| Molecular Formula | C11H14N2O |
| Molecular Weight | 190.24 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-616-0 |
| MDL | MFCD00136048 |
| SMILES | O=C1N(C[C@@]2([H])C[C@]3([H])CNC2)C3=CC=C1 |
| InChIKey | ANJTVLIZGCUXLD-DTWKUNHWSA-N |
| InChI | InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1 |
| PubChem CID | 10235 |
| Target Point | nAChR |
| Passage | Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | Cytisine is an alkaloid that is a partial agonist of the α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs) and a partial complete agonist that includes both β4 and α7 receptors. |
| Biological Activity | Cytisine 是一种生物碱，可在 Laburnum 和 Cytisus 等中提取得到。 Cytisine 是 α4β2 nAChRs的部分激动剂[1]，也是包含 β4 受体和 α7 受体的偏完全性激动剂[2]。 |
| In Vitro | Cytisine(2.5，5和10 mM)能够诱导HepG2细胞凋亡[3]。用Cytisine治疗增加了亚G1期细胞的百分比(P <0.01)。用Cytisine(2.5，5和10 mM)预孵育HepG2细胞可显著增加亚G1细胞群[3]。 |
| In Vivo | Cytisine(5 mg/kg，ip)吃得少，体重也比接受载体的人少[2]。 Cytisine替代期间相对于尼古丁的总颗粒摄入量增加，并且自我施用Cytisine的动物显著少于尼古丁[2]。 |
| Data Literature Source | [1]. Pabreza LA，et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39(1):9-12. [2]. Grebenstein PE，et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200. [3]. Yu L，et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39(3):1475-1484 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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