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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Serotonin HydrochlorideCAS：153-98-0
Molecular Formula：C10H12N2O·HCl
Molecular Weight：212.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to brown Solid
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| CAS | 153-98-0 |
| Name | Serotonin Hydrochloride |
| Molecular Formula | C10H12N2O·HCl |
| Molecular Weight | 212.68 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | Off-white to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-464-4 |
| MDL | MFCD00012686 |
| SMILES | OC1=CC2=C(NC=C2CCN)C=C1.[H]Cl |
| InChIKey | MDIGAZPGKJFIAH-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H |
| PubChem CID | 160436 |
| Target Point | 5-HT Receptor; COMT |
| Passage | Neuronal Signaling;GPCR & G Protein; Metabolic Enzyme&Protease |
| Background | Serotonin hydrochloride is a monoamine neurotransmitter and endogenous 5-HT receptor agonist in the CNS and an inhibitor of catechol O-methyltransferase (COMT). |
| Biological Activity | Serotonin hydrochloride 是 CNS 中的单胺神经递质和内源性 5-HT 受体激动剂。Serotonin hydrochloride 也是儿茶酚 O-甲基转移酶 (COMT) 的抑制剂其 Ki 值为 44 μM。[1-2] |
| In Vitro | 血清素盐酸盐是CNS中的单胺神经递质和内源性5-HT受体激动剂。血清素盐酸盐还抑制儿茶酚O-甲基转移酶(COMT)，这种酶通过与儿茶酚底物结合的位点的非竞争性结合，有助于模拟疼痛的感知，其结合亲和力与儿茶酚本身的结合亲和力相当(Ki = 44μM)。结果表明，添加100μM盐酸血清素降低了COMT的反应速度[1]。 |
| In Vivo | 与盐水处理的对照相比，血清素盐酸盐产生强烈的超敏反应(p <0.001)[1]。在诱导DSS结肠炎后，接受IL-13 - / - 接受载体的IL-13 - / - 小鼠在接受血清素盐酸盐的小鼠中观察到结肠5-HT含量的显着增加[2]。 |
| Cell Experiment | 对于巨噬细胞培养，在有或没有葡聚糖硫酸钠(DSS)处理的情况下从WT和IL-13 - / - 小鼠收集腹膜腔细胞并培养。将细胞以3.0×10 6个细胞/毫升的浓度接种，并用脂多糖(LPS)处理;(100ng / mL)或血清素盐酸盐(10-10M)24小时。收集培养上清液并储存在-80℃直至使用蛋白质阵列系统测定细胞因子水平[2]。 |
| Animal Experiment | 通过在饮用水中口服施用5％DSS 5天诱导葡聚糖硫酸钠(DSS)结肠炎。在另一个实验中，IL-13 - / - 小鼠皮下注射100mg / kg盐酸5-羟色胺(5-HTP)，每天两次，在诱导DSS结肠炎前3天开始，持续8天; 而对照IL-13 - / - 小鼠接受盐水作为载体。在每次实验结束时通过颈椎脱位进行安乐死之前或者如果它们达到预定的终点(即，体重减少≥20％和/或身体状况显着恶化)，将动物麻醉[2]。 |
| Data Literature Source | [1]. Tsao D， et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13; 8:25. [2]. Shajib MS， et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28; 8 (8) :e72774 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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