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My CartCAS：35212-22-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 35212-22-7 |
| Name | Ipriflavone |
| Molecular Formula | C18H16O3 |
| Molecular Weight | 280.32 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-641-0 |
| MDL | MFCD00221719 |
| SMILES | O=C1C(C2=CC=CC=C2)=COC3=CC(OC(C)C)=CC=C13 |
| InChIKey | SFBODOKJTYAUCM-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3 |
| PubChem CID | 3747 |
| Target Point | Others |
| Passage | Others |
| Background | Ipriflavone is an isoflavone derivative. |
| Biological Activity | Ipriflavone是一种用于抑制骨吸收的异黄酮衍生物。[1-3] |
| In Vitro | Ipriflavone抑制MDA-231细胞的增殖和DNA合成，并阻断配体诱导的EGFR Tyr(845)的磷酸化。 Ipriflavone不会促进MDA-231细胞的凋亡[1]。 Ipriflavone还促进新生大鼠颅骨成骨细胞样细胞的钙沉积和矿化结节的形成以及碱性磷酸酶的活性[2]。 |
| In Vivo | 每日口服12mg /小鼠的异丙黄酮可显著抑制新的溶骨性骨转移的发展和已确定的溶骨性病变的进展，从而延长荷瘤小鼠的寿命。 Ipriflavone减少了骨癌界面破骨细胞的数量，对宿主没有严重的副作用[1]。用异丙黄酮治疗1个月可增加骨密度，改善成年大鼠雄性骨骼的生物力学特性，而不改变矿物质成分[3] |
| Cell Experiment | 在Ipriflavone(1，10或50μM)或乙醇存在下，将MDA-231细胞接种在补充有10％FBS的DMEM中的35mm培养皿中。温育48小时后，用含有相同浓度的异丙黄酮或乙醇的新鲜培养基更换培养基。从初始接种后孵育24，48，72和96小时后，用台盼蓝处理细胞以估计活细胞的数量[1]。 |
| Animal Experiment | 大鼠：为了评估异丙黄酮对骨的生物力学性质和矿物质组成的潜在影响，给成年雄性大鼠口服两剂(200或400mg/kg体重)的依普黄酮1个月。骨生物力学通过振动阻尼，应变能损失指数和冲击强度来评估[3]。小鼠：将异丙黄酮悬浮于含有0.5％(w/v)甲基纤维素的水中，并以每天6或12mg/0.2mL口服给予小鼠，相当于200或400mg/kg体重。将MDA-231细胞皮下注射到裸鼠的肩胛间隙(第0天)，然后从第1天到第27天口服给予异丙黄酮(6或12mg /小鼠)或甲基纤维素溶液。肿瘤生长分析两次一周通过测量肿瘤体积[1]。 |
| Data Literature Source | [1]. Iisaki T，et al. Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model. Int J Cancer. 2002 Aug 1;100(4):381-7. [2]. Hagiwara H，et al. Ipriflavone down-regulates endothelin receptor levels during differentiation of rat calvarial osteoblast-like cells. J Biochem. 1999 Jul;126(1):168-73. [3]. Civitelli R，et al. Ipriflavone improves bone density and biomechanical properties of adult male rat bones. Calcif Tissue Int. 1995 Mar;56(3):215-9. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Ipriflavone是一种异黄酮衍生物。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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