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My CartCAS：3681-93-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 3681-93-4 |
| Name | Vitexin |
| Molecular Formula | C21H20O10 |
| Molecular Weight | 432.38 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 222-963-8 |
| MDL | MFCD00017456 |
| SMILES | OC1=CC=C(C2=CC(C(C(O)=CC(O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C3O2)=O)C=C1 |
| InChIKey | SGEWCQFRYRRZDC-VPRICQMDSA-N |
| InChI | InChI=1S/C21H20O10/c22-7-14-17(27)18(28)19(29)21(31-14)16-11(25)5-10(24)15-12(26)6-13(30-20(15)16)8-1-3-9(23)4-2-8/h1-6,14,17-19,21-25,27-29H,7H2/t14-,17-,18+,19-,21+/m1/s1 |
| PubChem CID | 5280441 |
| Target Point | Others |
| Passage | Others |
| Background | Vitexin is a C-glycosylated flavonoid with a wide range of pharmacological activities， including antioxidant， anticancer， anti-inflammatory， antialgic and neuroprotective properties. |
| Biological Activity | Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.[1-2] |
| In Vitro | Vitexin promotes cell viability，inhibits apoptosis，and decreases inflammatory cytokines. These protective effects are related to the regulation of ER stress by vitexin in chondrocytes[2]. |
| In Vivo | Vitexin ameliorates sexual dysfunction and fertility impairments in male diabetic mice possibly by modulating the hypothalamus-pituitary-gonadal axis[1]. |
| Cell Experiment | Chondrocytes(2 × 105 cells)were planted in a 96-well plate and treated with various doses of vitexin，with or without IL-1β(10 ng/mL)，for 1 day according to the requirements of the experiment. All of the chondrocytes were incubated for 2 h with cholecystokinin octapeptide(CCK-8)(10 μL)and the absorbance of the reaction at 450 nm was then quantified using a micro-plate reader.[2] |
| Animal Experiment | Animal Models: adult male mice(25–30 g); Dosages: 10，20 and 40 mg/kg; Administration: oral[1] |
| Data Literature Source | [1] Li ZM，et al. Chem Biol Interact. 2018，297:119-129. [2] Xie CL，et al. Food Funct. 2018，doi: 10.1039/c8fo01509k. |
| Unit | Bottle |
| Specification | 5mg 20mg |
Vitexin 是一种 c-糖基化的黄酮，存在于多种药用植物中。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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