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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Cucurbitacin BCAS：6199-67-3
Molecular Formula：C32H46O8
Molecular Weight：558.7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 6199-67-3 |
| Name | Cucurbitacin B |
| Molecular Formula | C32H46O8 |
| Molecular Weight | 558.7 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07778083 |
| SMILES | O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C([C@@H](O)C[C@@]4([H])[C@]3(C)C2=O)=O |
| InChIKey | IXQKXEUSCPEQRD-DKRGWESNSA-N |
| InChI | InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1 |
| PubChem CID | 5281316 |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Cucurbitacin B, a tetracyclic triterpenoid compound in cucurbitacin, can interfere with microtubule polymerization and is often used in the development of long-acting anticancer compounds. |
| Biological Activity | Cucurbitacin B，是一种提取自葫芦科植物的氧化四环三萜类物质，用作长效的抗癌药物，可干扰微管聚合。[1] |
| In Vitro | Cucurbitacin B通过影响细胞骨架以及JNK通路抑制了五个GBM细胞系U87，U118，U343，U373和T98G的生长，其ED50值介于5 nM和100 nM之间。Cucurbitacin B还将GBM细胞系细胞周期阻断在G2/M阶段，降低了细胞的迁移，诱导了细胞的凋亡。[1] 在人源乳腺癌细胞系中，Cucurbitacin B抑制了细胞的生长，其ED50值介于30.3 nM和418 nM之间，并且诱导了细胞骨架的损伤。[2] 此外，Cucurbitacin B还显示了免疫调节及抗炎症作用，主要依赖于其通过活化Nrf2而对heme oxygenase-1表达的诱导。 [3] |
| In Vivo | 在移植有MDA-MB-231肿瘤细胞的裸鼠中，Cucurbitacin B(1 mg/kg，i.p.)抑制了55%的肿瘤生长，并且导致了血糖水平的降低。[2] |
| Data Literature Source | [1] Yin D，et al. Int J Cancer. 2008，123(6)，1364-1375. [2] Wakimoto N，et al. Cancer Sci. 2008，99(9)，1793-1797. [3] Kim M. et al. Immunopharmacol Immunotoxicol. 2015，37(5)，473-480. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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