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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > ACY-738CAS：1375465-91-0
Molecular Formula：C14H14N4O2
Molecular Weight：270.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1375465-91-0 |
| Name | ACY-738 |
| Molecular Formula | C14H14N4O2 |
| Molecular Weight | 270.29 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28347706 |
| SMILES | O=C(NO)C(C=N1)=CN=C1NC2(CC2)C3=CC=CC=C3 |
| InChIKey | LIIWIMDSZVNYHY-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17) |
| PubChem CID | 57381425 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | ACY-738 N-hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide is an HDAC inhibitor. |
| Biological Activity | ACY-738以低纳摩尔浓度抑制HDAC6，IC50为1.7 nM。其对HDAC6的选择性比对其他I类HDACs高60-1500倍。[1-2] |
| In Vivo | ACY-738在小鼠脑内诱导α-tubulin乙酰化急剧增加、刺激小鼠在一个新的、不熟悉的环境产生探究行为。ACY-738具有类似于抗抑郁活性。ACY-738在血浆中的消除速度迅速，半衰期为12分钟。2小时后，其浓度低于10 ng/ml。ACY-738可迅速分布至脑内，使中枢神经系统中的药物暴露量与其他周围组织类似[1]。在NZB/W小鼠中，ACY-738通过调节骨髓中的B细胞发育，降低全身性红斑狼疮病症中的几个特征。ACY-738可在早期发育阶段增加B细胞的百分比，而在晚期前B细胞阶段降低其细胞百分比。它可调节在全身性红斑狼疮中功能失调的发育检查点，从而调节骨髓细胞中B细胞的发育[2]。 |
| Animal Experiment | Animal Models: Male NIH Swiss mice; Dosages: 5 mg/kg; Administration: i.p.[1] |
| Data Literature Source | [1] Jochems J，et al. Neuropsychopharmacology. 2014，39(2):389-400. [2] Regna NL，et al. Clin Immunol. 2016，162:58-73. |
| Unit | Bottle |
| Specification | 5mg 10mg |
是一种HDAC抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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