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My CartCAS：58569-55-4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 58569-55-4 |
| Name | Tyr-Gly-Gly-Phe-Met-OH |
| Molecular Formula | C27H35N5O7S |
| Molecular Weight | 573.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 261-335-8 |
| SMILES | O=C(O)[C@H](CCSC)NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@@H](N)CC2=CC=C(O)C=C2)=O)=O)=O)=O |
| InChIKey | YFGBQHOOROIVKG-FKBYEOEOSA-N |
| InChI | InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1 |
| PubChem CID | 443363 |
| Target Point | Opioid Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Tyr-Gly-Gly-Phe-Met-OH exerts immunological activity by binding to the opioid receptor. |
| Biological Activity | Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor)，可调控人类免疫功能，抑制肿瘤生长。[1] |
| In Vitro | 甲硫氨酸脑啡肽(MENK)是一种内源性神经肽，在神经内分泌和免疫系统中都起着至关重要的作用。 MENK被认为具有免疫调节活性，通过与免疫和癌细胞上的阿片受体结合而具有癌症生物治疗活性。 MENK还可以通过与癌细胞上或癌细胞中的阿片受体结合来改变肿瘤微环境。所有这些作用机制都具有生物学意义和用于癌症免疫疗法的潜力。此外，他们揭示了内分泌和免疫系统之间的关系[1]。 |
| Data Literature Source | [1]. Zhao D，et al. Methionine enkephalin，its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 25mg |
Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor)发挥免疫学活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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