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My CartCAS：1404-93-9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥96%
Appearance：White to off-white Solid
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| CAS | 1404-93-9 |
| Name | Vancomycin Hydrochloride |
| Molecular Formula | C66H75Cl2N9O24·HCl |
| Molecular Weight | 1485.71 |
| Solubility | Soluble in Water ≥50mg/mL |
| Purity | HPLC≥96% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 604-193-8 |
| MDL | MFCD03613611 |
| SMILES | C[C@@H]1O[C@@]([H])(O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC3=C(OC4=C(Cl)C=C([C@@H](O)[C@](NC([C@]5([H])NC6=O)=O)(C(N[C@]([H])(C(O)=O)C7=CC(O)=CC(O)=C7C8=C(O)C=CC5=C8)=O)[H])C=C4)C=C([C@@]6([H])NC([C@H](CC(N)=O)NC9=O)=O)C=C3OC%10=CC=C([C@@H](O)[C@H]9NC([C@H](NC)C(C)(C)C)=O)C=C%10Cl)C[C@](C)(N)[C@@H]1O.[H]Cl |
| InChIKey | LCTORFDMHNKUSG-XTTLPDOESA-N |
| InChI | InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1 |
| PubChem CID | 6420023 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Vancomycin hydrochloride works by inhibiting the second stage of cell wall synthesis in susceptible bacteria, also alters the permeability of cell membranes and selectively inhibits ribonucleic acid synthesis. |
| Biological Activity | Vancomycin hydrochloride是用于治疗细菌感染 (bacterial) 的抗生素。 它通过抑制易感细菌的细胞壁合成的第二阶段起作用。 Vancomycin还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。[1-3] |
| In Vitro | 万古霉素是一种大的糖肽化合物，分子量为1450 Da [1]。万古霉素是一种独特的糖肽，在结构上与任何目前可用的抗生素无关。它还具有抑制易感细菌的细胞壁合成的第二阶段的独特作用模式。万古霉素对大量革兰氏阳性细菌有活性，例如金黄色葡萄球菌(Staphylococcus aureus)，金黄色葡萄球菌(Staph)。表皮葡萄球菌无乳链球菌博维斯，Str。变形链球菌，草绿色链球菌，肠球菌[2]。 |
| In Vivo | 万古霉素静脉内给药，标准输注时间至少为1小时，以最大限度地减少输注相关的不良反应。具有正常肌酸酐清除率的受试者，万古霉素具有30分钟至1小时的α-分布期和6-12小时的β-消除半衰期。分布容积为0.4-1L/kg。万古霉素与蛋白质的结合范围为10％至50％。影响万古霉素总活性的因素包括其组织分布，接种量和蛋白结合效应[1]。感染小鼠的万古霉素治疗与改善临床，腹泻和组织病理学评分以及治疗期间的存活率相关[3]。 |
| Animal Experiment | 小鼠：进行一组实验，其中感染的小鼠每天用万古霉素(50mg/kg)治疗1，2，3或5天，并在感染后观察21天或每天用万古霉素(20mg/kg)观察持续5天或10天，并在感染后监测15天[3]。 |
| Data Literature Source | [1]. Rybak MJ，et al. The pharmacokinetic and pharmacodynamic properties of vancomycin. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S35-9. [2]. Watanakunakorn C，et al. Mode of action and in-vitro activity of vancomycin. J Antimicrob Chemother. 1984 Dec;14 Suppl D:7-18. [3]. Warren CA，et al. Vancomycin treatment's association with delayed intestinal tissue injury，clostridial overgrowth，and recurrence of Clostridium difficile infection in mice. Antimicrob Agents Chemother. 2013 Feb;57(2):689-96 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in Water 100mg |
Vancomycin hydrochloride是通过抑制易感细菌的细胞壁合成的第二阶段起作用，还可改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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