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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Sodium ButyrateCAS：156-54-7
Molecular Formula：C4H7NaO2
Molecular Weight：110.09
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 156-54-7 |
| Name | Sodium Butyrate |
| Molecular Formula | C4H7NaO2 |
| Molecular Weight | 110.09 |
| Solubility | Soluble in Water ≥100mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-857-6 |
| MDL | MFCD00002816 |
| SMILES | CCCC([O-])=O.[Na+] |
| InChIKey | MFBOGIVSZKQAPD-UHFFFAOYSA-M |
| InChI | InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1 |
| PubChem CID | 5222465 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Sodium Butyrate is a short-chain fatty acid that inhibits histone deacetylases. |
| Biological Activity | Sodium Butyrate是一种短链脂肪酸，可以抑制组蛋白去乙酰化酶。[1-5] |
| In Vitro | 丁酸钠诱导形态学变化，抑制细胞增殖并损害NPC细胞的细胞活力。丁酸钠(1，5，10mM)对NPC细胞具有细胞毒性，在5-8F和6-10B细胞中诱导细胞活力的剂量和时间依赖性降低。丁酸钠通过激活线粒体凋亡轴诱导鼻咽癌细胞凋亡。此外，SOCE抑制和破坏CRAC通道可以减弱丁酸钠诱导的细胞凋亡[1]。丁酸钠显著降低细胞活力，同时降低p-mTOR和PCNA蛋白的水平。丁酸钠以剂量依赖性方式诱导细胞周期停滞在G0/G1期并减少S期细胞数量。此外，较高浓度的丁酸钠(1，5，10mM)增加p21，p27和促凋亡bak基因的相对表达，以及p21Waf1/Cip1，p27Kip1，cyclinD3，CDK4和Cleave-caspase3的蛋白水平。)，cyclinD1和CDK6的水平降低5和10mM丁酸盐[3]。 |
| In Vivo | HI后立即给予丁酸钠(300mg/kg，sc)，与未处理的动物相比，提供了几乎完全的神经保护作用。丁酸钠给药导致小侧神经细胞数量增加至同侧的载体治疗动物的150％。在新生儿缺氧缺血后，丁酸钠促进小胶质细胞从M1-到M2样表型的极化[2]。丁酸钠(300 mg/kg，sc)与AK-7(20 mg/kg，ip)联合使用可显著减轻探索新物体所花费的时间，减少Ki67阳性细胞和DCX-的数量减少小鼠齿状回中的免疫反应性成神经细胞。此外，丁酸钠可逆转SIRT2相关的年龄表型[4]。 |
| Cell Experiment | 将细胞以2，000个细胞/孔的密度接种在96孔板中，其中200μL培养基含有不同浓度的丁酸钠。然后，将细胞连续培养72小时。每24小时，将20μL5mg/ mL MTT溶液加入相应的孔中，并将细胞再培养4小时。然后，用150μL二甲基亚砜代替溶液，然后在室温下温和搅拌板15分钟。最后，测量492nm处的吸光度以代表细胞活力。 |
| Animal Experiment | 对7日龄大鼠幼鼠进行单侧颈动脉结扎，然后进行60分钟的缺氧(7.6％O2)。丁酸钠(300mg/kg)以5天的方式给药，在缺氧暴露后立即给予第一次注射。在损伤后6天通过苏木精 - 伊红染色评估同侧半球的损伤。在24和48小时和6天收集样品。 |
| Data Literature Source | [1]. Huang W，et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929 [2]. Jaworska J，et al. The potential neuroprotective role of a histone deacetylase inhibitor，sodium butyrate，after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34 [3]. Qiu Y，et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27 [4]. Jung HY，et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory，cell proliferation，and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230 [5]. Wang P，et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in Water 500mg |
是一种短链脂肪酸，可以抑制组蛋白去乙酰化酶。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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