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My CartCAS：7432-28-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 7432-28-2 |
| Name | Schisandrol A |
| Molecular Formula | C24H32O7 |
| Molecular Weight | 432.51 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00905761 |
| SMILES | O[C@]1(C)[C@@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C(OC)C(OC)=C(OC)C=C3C1 |
| InChIKey | YEFOAORQXAOVJQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3 |
| PubChem CID | 23915 |
| Target Point | Others |
| Passage | Others |
| Background | It is a compound with biological activities such as anti-cancer and anti-inflammatory. |
| Biological Activity | Schisandrin (Schizandrin)， a dibenzocyclooctadiene lignan， is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant， hepatoprotective， anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats[1][2][3]. |
| In Vitro | Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production， iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells[1].Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production， COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages[1].Schisandrin inhibits the SK-HEP-1， SNU-638， and T47D cells proliferation， with IC50s of 42.0， 53.1， and 40.0 μM， respectively[3].Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance[4]. |
| In Vivo | Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice[1].Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response， and enhances tremors induced by Oxotremorine in rats[2]. |
| Data Literature Source | [1]. Guo LY，et，al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 2008 Sep 4;591(1-3):293-9. [2]. Egashira N，et，al. Schizandrin reverses memory impairment in rats. Phytother Res. 2008 Jan;22(1):49-52. [3]. Min HY，et，al. Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. Bioorg Med Chem Lett. 2008 Jan 15;18(2):523-6. [4]. Zhang ZL，et，al. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation. Breast Cancer. 2018 Mar;25(2):233-242. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
是具有抗癌和抗炎症等生物活性的化合物。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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