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My CartCAS：61281-37-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 61281-37-6 |
| Name | Schisandrin B |
| Molecular Formula | C23H28O6 |
| Molecular Weight | 400.46 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00210555 |
| SMILES | C[C@H](C1)[C@@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC |
| InChIKey | RTZKSTLPRTWFEV-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3 |
| PubChem CID | 108130 |
| Target Point | Others |
| Passage | Others |
| Background | Schisandrin B isa biphenyl cycloctadiene derivative that has antioxidant activity. |
| Biological Activity | Schisandrin B (SchB)， an active ingredient of Fructus schisandrae， on ATR activity in DNA damage response. [1] |
| In Vitro | SchB treatment significantly decreased the viability of A549 adenocarcinoma cells after UV exposure. Importantly，SchB treatment inhibited both the phosphorylation levels of ATM and ATR substrates，as well as the activity of the G2/M checkpoint in UV-exposed cells. The protein kinase activity of immunoaffinity-purified ATR was dose-dependently decreased by SchB in vitro(IC(50): 7.25 muM)，but the inhibitory effect was not observed in ATM，Chk1，PI3K，DNA-PK，and mTOR. The extent of UV-induced phosphorylation of p53 and Chk1 was markedly reduced by SchB in ATM-deficient but not siATR-treated cells.[1] |
| Data Literature Source | [1]. Nishida H，Tatewaki N，Nakajima Y，Magara T，Ko KM，Hamamori Y，Konishi T. Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response. Nucleic Acids Res. 2009 Sep;37(17):5678-89. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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