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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Rosmarinic acidCAS：20283-92-5
Molecular Formula：C18H16O8
Molecular Weight：360.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 20283-92-5 |
| Name | Rosmarinic acid |
| Molecular Formula | C18H16O8 |
| Molecular Weight | 360.31 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 606-487-1 |
| MDL | MFCD00017740 |
| SMILES | OC([C@H](OC(/C=C/C1=CC(O)=C(O)C=C1)=O)CC2=CC(O)=C(O)C=C2)=O |
| InChIKey | DOUMFZQKYFQNTF-WUTVXBCWSA-N |
| InChI | InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 |
| PubChem CID | 5281792 |
| Target Point | MAO(Monoamine Oxidase) |
| Passage | Neuronal Signaling |
| Background | Rosmarinic acid can inhibit MAO-A, MAO-B, and COMT, exhibiting strong antioxidant and anti-inflammatory activities, as well as antibacterial, antiviral, and anti-tumor activities. |
| Biological Activity | 迷迭香酸 (Rosmarinic acid) 是一种天然多酚物质，具有抗氧化、抗炎活性。[1-3] |
| IC50 | 50.1μM(MAO-A)，184.6μM(MAO-B)，26.7μM(COMT)[1] |
| In Vitro | 迷迭香酸(RA)显示出体外多功能特征，其特征在于抗氧化作用，和单胺氧化酶(MAO-A和MAO-B)和儿茶酚-O-甲基转移酶(COMT)抑制。迷迭香酸对羟基和一氧化氮自由基具有抗氧化作用(IC50分别为29.4和140μM)，并且抑制脂质过氧化(IC50为19.6μM)[1]。迷迭香酸(RA)通过清除由UVB诱导的细胞内ROS而发挥显著的细胞保护作用。在H2O2处理的细胞中，2.5μM迷迭香酸清除60％的细胞内ROS，相比之下，77％的细胞内ROS清除N-乙酰-L-半胱氨酸(NAC)[2]。 |
| In Vivo | 迷迭香酸(RA)是植物中广泛存在的酚酯化合物，特别是唇形科植物中的那些，例如迷迭香(Rosmarinus officinali)，丹参(Salvia miltiorrhiza)和夏枯草(Prunella vulgaris)。迷迭香酸通过NF-κB和STAT3活化的双重抑制抑制葡聚糖硫酸钠(DSS)诱导的小鼠中的结肠炎症。在DSS诱导的结肠炎模型中，迷迭香酸(30，60 mg/kg，po)治疗显著减弱了细胞因子的产生[3]。 |
| Cell Experiment | 用迷迭香酸(0.625，1.25，2.5或5μM)处理人角质形成细胞(HaCaT细胞)并在1小时后暴露于UVB辐射。然后将它们在37℃下孵育48小时。此时，向每个孔中加入MTT以获得200μL的总反应体积。温育4小时后，通过抽吸除去上清液。将每个孔中的甲crystals晶体溶解在二甲基亚砜(DMSO;150μL)中，并在扫描多孔分光光度计上测量540nm处的吸光度[2]。 |
| Animal Experiment | 小鼠[3]通过给予含有5％(w/v)DSS的小鼠自由饮水7天来诱导实验性结肠炎。每天仔细监测每组的小鼠以确认它们已经消耗了大约等体积的含有DSS的水。对于每个实验，将小鼠分成五个实验组(n = 10 /组)。第一组保持为载体处理对照，第二组仅在实验期间给予DSS饮用水。其他三组由接受5％DSS的小鼠组成，每天施用5-ASA(75mg/kg /天口服)或迷迭香酸(30或60mg/kg /天口服)，持续7天。对照组每天给予载体7天，视情况而定。每种药物的给药与DSS治疗同时开始。 |
| Data Literature Source | [1]. Andrade JM，et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45. [2]. Fernando PM，et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84. [3]. Jin BR，et al. Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. Sci Rep. 2017 Apr 6;7:46252. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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