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My CartCAS：137281-23-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 137281-23-3 |
| Name | Pemetrexed |
| Molecular Formula | C20H21N5O6 |
| Molecular Weight | 427.41 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 680-625-9 |
| MDL | MFCD19105065 |
| SMILES | O=C1NC(N)=NC2=C1C(CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)=CN2 |
| InChIKey | WBXPDJSOTKVWSJ-ZDUSSCGKSA-N |
| InChI | InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1 |
| PubChem CID | 135410875 |
| Target Point | Antifolate |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | Pemetrexed is a folic acid antagonist. Inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide nucleotide formyltransferase (GARFT). |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
是一种叶酸拮抗剂。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Pan Y, et al. Microsyst Nanoeng. 2020 Mar 9;6:23.
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