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My CartCAS：1405-10-3
Molecular Formula：C23H52N6O25S3
Molecular Weight：908.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1405-10-3 |
| Name | Neomycin Sulfate |
| Molecular Formula | C23H52N6O25S3 |
| Molecular Weight | 908.88 |
| Solubility | Soluble in Water ≥50mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 215-773-1 |
| MDL | MFCD00037007 |
| SMILES | O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4] |
| InChIKey | OIXVKQDWLFHVGR-WQDIDPJDSA-N |
| InChI | InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 |
| PubChem CID | 197162 |
| Target Point | Bacterial;Phospholipase C (PLC) |
| Passage | Metabolic Enzyme&Protease; Anti-infection |
| Background | It is an aminoglycoside antibiotic that exerts antibacterial activity through irreversible binding of nuclear 30S ribosomal subunits， thereby blocking the synthesis of bacterial proteins， and is often used to screen prokaryotic and eukaryotic cells with Neo resistance genes. |
| Biological Activity | Neomycin sulfate是用于预防或治疗 细菌 感染的氨基糖苷类抗生素。[1-4] |
| Data Literature Source | [1]. Carney，D.H.，et al. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Cell，1985. 42(2): p. 479-88. [2]. Nakashima，S.，et al. Neomycin is a potent agent for arachidonic acid release in human platelets. Biochem Biophys Res Commun，1987. 146(2): p. 820-6. [3]. Liscovitch，M.，et al.，Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem J，1991. 279 ( Pt 1): p. 319-21. [4]. Huang K，et al. CRAC channel is inhibited by neomycin in a Ptdlns(4，5)P2-independent manner. Cell Biochem Funct. 2015 Mar;33(2):97-100 |
| Unit | Bottle |
| Specification | 200mg 10mM*1mL in Water 500mg 1g 5g |
Neomycin Sulfate是一种氨基糖苷类抗生素，通过核 30S 核糖体亚单位的不可逆结合发挥抗菌活性 (antibacterial)，从而阻断细菌蛋白质的合成。
Neomycin Sulfate也是一种已知的磷脂酶C (PLC) 抑制剂。
据报道，Neomycin Sulfate能抑制血管生成素的核转位和血管生成素诱导的细胞增殖和血管生成。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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