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My CartCAS：25389-94-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 25389-94-0 |
| Name | Kanamycin Sulfate |
| Molecular Formula | C18H36N4O11·H2SO4 |
| Molecular Weight | 582.58 |
| Solubility | Soluble in Water ≥100mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 246-933-9 |
| MDL | MFCD00070253 |
| SMILES | OS(O)(=O)=O.O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@H](CN)[C@@H](O)[C@@H]1O |
| InChIKey | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| InChI | InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1 |
| PubChem CID | 441374 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Kanamycin sulfate is a broad-spectrum aminoglycoside antibiotic with a similar antibacterial spectrum to that of neomycin. It mainly binds to the 30S subunit of the bacterial ribosome and inhibits bacterial protein synthesis. |
| Biological Activity | Kanamycin sulfate是氨基糖苷类杀菌抗生素，其通过与细菌30S核糖体结合起作用。[1-4] |
| In Vitro | 浓度高于0.0025％的硫酸卡那霉素对双歧双歧杆菌的生长具有显著的抑制作用，并且在孵育12小时或24小时时对其他四种益生菌没有影响。对于B.bifidum的选择性计数，MRS培养基中硫酸卡那霉素的最佳选择浓度为0.005％[3]。 |
| In Vivo | 由卡那霉素(500mg/kg /天)引起的DCN的神经元损伤是可逆的，并且通过JNK1介导的大鼠Bcl-2途径的磷酸化，在DCN上卡那霉素的神经毒性过程中自噬被上调。在卡那霉素给药期后第1天血清BUN和Cr水平均升高。与对照组相比，在卡那霉素给药后第1，7和14天，表达LC3的神经元增加。卡那霉素治疗以时间依赖的方式导致自噬增加[1]。硫酸卡那霉素(5 mg/kg)和氨苄西林钠(10 mg/kg)分别肌肉注射(im)，然后一起给予5匹小马，并且在发炎的滑液中氨苄青霉素浓度超过5 mg/mL约2.5 h注射后，硫酸卡那霉素浓度超过2 mg/mL，在小马中持续7 h [2]。 |
| Animal Experiment | 六十六只雄性Sprague-Dawley大鼠(初始体重125-150g，5-6周龄)可自由饮水和定期饮食，并且在第一次治疗前允许1周适应。将动物随机分成一个对照组和七个实验组。对照组大鼠(n = 10)皮下注射等体积的载体(0.9％盐水)10天，与卡那霉素处理组相同，但不含卡那霉素。实验组(每组n = 56，8：分别给予卡那霉素后1，7，14，28，56，70和140天)通过皮下注射接受500mg硫酸卡那霉素/ kg /天，持续10天。每天监测动物体重，并相应地调整卡那霉素的注射剂量。听觉阈值由ABR测试。每只动物进行两次试验，首先在给药开始之前，然后在卡那霉素处理后的不同观察时间点进行。 ABR测量的细节在别处描述。 |
| Data Literature Source | [1]. Fan GR，et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. pii: S0006-8993(13)00068-1. [2]. Mohamed el SW，et al. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4. [3]. Guo WS，et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research，2011，366，490-493. [4]. Firth EC，et al. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J Vet Pharmacol Ther. 1988 Mar;11(1):56-62 |
| Unit | Bottle |
| Specification | 10mM*1mL in Water 200mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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