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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > GlibenclamideCAS：10238-21-8
Molecular Formula：C23H28ClN3O5S
Molecular Weight：494
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 10238-21-8 |
| Name | Glibenclamide |
| Molecular Formula | C23H28ClN3O5S |
| Molecular Weight | 494 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 233-570-6 |
| MDL | MFCD00056625 |
| SMILES | ClC1=CC(C(NCCC2=CC=C(S(NC(NC3CCCCC3)=O)(=O)=O)C=C2)=O)=C(OC)C=C1 |
| InChIKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) |
| PubChem CID | 3488 |
| Target Point | Potassium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a sulfonylurea compound that regulates insulin production. It is also a selective, ATP-sensitive inhibitor of potassium channels. |
| In Vitro | Glibenclamide(Brown adipocytes; 10 μΜ; 1 day)has no effect on adipocyte differentiation. Glibenclamide(Ucp1-2A-GFP brown adipocyte)significantly increases UCP1 expression. Glibenclamide directly binds and blocks the SUR1 subunits of ATP-dependent potassium channels(KATP)and consequently increases insulin secretion from the pancreatic β cells[1]. |
| In Vivo | Glibenclamide(2 mg/kg; p.o.)increases of insulin release and rapid drop of blood glucose level[1]. |
| Data Literature Source | [1]. Qiu Y，et al. Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade. iScience. 2020;23(9):101446. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
It is a sulfonylurea compound that regulates insulin production, inhibits hepatic glycogenolysis and glycoconeogenesis by increasing portal vein insulin levels or acting directly on the liver, reducing liver production and output of glucose. It is a selective, ATP-sensitive inhibitor of potassium channels.
Examples of using this product（for reference only）
In Vivo:
Mice（Male C57BL/6 mice, 6–8 weeks of age and weighed 20–25g; 5 mg/kg glibenclamide, 1次/d，7d，I.P）:
Forty-eight mice that were 6–8 weeks of age and weighed 20–25 g were used for the study. The mice were injected intraperitoneally once a day for a week with 5 mg/kg glibenclamide (Solarbio, China), 15 mg/kg oridonin or the formulation vehicle of DMSO diluted with stroke-physiological saline solution. To minimize toxicity to mice, the final concentration of DMSO did not exceed 2%.
Reference：
Liu H, Gu C, Liu M, Liu G, Wang Y. NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury. Biochem Pharmacol. 2020 Jul;177:113998. doi: 10.1016/j.bcp.2020.113998. Epub 2020 Apr 27. PMID: 32353421.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Liu H, et al. Biochem Pharmacol. 2020 Jul;177113998.
Liu H, et al. Biochem Pharmacol. 2020 Jul;177113998.
Liu H, et al. Biochem Pharmacol. 2020 Jul;177113998.
Sorry, there is no more information.
NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury
Click to check >>Author：Liu H. Gu C. Liu M. Liu G. Wang Y
IF：5.2860
Publish_to：Biochem Pharmacol
PMID：32353421
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