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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Ginsenoside RfCAS：52286-58-5
Molecular Formula：C42H72O14
Molecular Weight：801.01
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 52286-58-5 |
| Name | Ginsenoside Rf |
| Molecular Formula | C42H72O14 |
| Molecular Weight | 801.01 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00210509 |
| SMILES | C[C@@]([C@@]12C)(C[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]3O)([H])[C@@H]3O[C@]([C@@H]([C@@H](O)[C@@H]4O)O)([H])O[C@@H]4CO)[C@@]5([H])C6(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC2)([H])[C@]5(CC[C@@H]6O)C |
| InChIKey | UZIOUZHBUYLDHW-XUBRWZAZSA-N |
| InChI | InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,52)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-37-34(32(50)30(48)25(19-44)55-37)56-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,39+,40+,41+,42-/m0/s1 |
| PubChem CID | 441922 |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Ginsenoside Rf inhibits N-type Ca2+ channels. |
| Biological Activity | Ginsenoside Rf 是人参根的一种微量成分。 Ginsenoside Rf 抑制 N 型 Ca2+ 通道。[1-2] |
| In Vitro | 人参皂苷Rf是皂苷，其在人参中仅以微量存在。在饱和浓度下，人参皂甙Rf快速且可逆地抑制大鼠感觉神经元中的N型和其他高阈值Ca2 +通道达到与最大剂量阿片类药物相同的程度。该作用是剂量依赖性的(半最大抑制：40μM)，并且通过用百日咳毒素(G(o)和Gi GTP结合蛋白的抑制剂)预处理神经元实际上消除了它。人参皂甙Rf还抑制杂交F-11细胞系中的Ca2 +通道[1]。 |
| In Vivo | 由于感觉神经元中Ca 2+通道的抑制有助于阿片类药物的抗伤害感受，因此测试了人参皂苷Rf的镇痛作用。使用两种单独的强直性疼痛测定法在小鼠中全身施用人参皂甙Rf，发现剂量依赖性抗伤害感受：在醋酸腹部收缩试验中，ED50为56±9 mg/kg，浓度与阿司匹林和对乙酰氨基酚相似在相同的测定中;在双相福尔马林试验的强直期，ED50为129±32 mg/kg [2]。 |
| Animal Experiment | 小鼠[2]在所有体内实验中使用远交Swiss-Webster原种的幼稚，成年(7-12周龄)小鼠。将小鼠带到安静的测试室，并适应桌面有机玻璃观察室(30厘米高;直径30厘米)30分钟。然后将它们称重并注射人参皂甙Rf(25，50或75mg/kg)或载体(在一次实验中先用纳洛酮或盐水)。 20分钟后，腹膜内(ip)以10mL/kg的体积注射0.9％的冰醋酸溶液。在接下来的30分钟内，计算收缩(扭动)的数量 - 腹部肌肉组织的强烈收缩，伴随背部的背屈和后肢的伸展 - 并在5分钟的块中记录。由一位经验丰富的实验者同时观察四只小鼠(每个室一个)。为了控制伴随该伤害性测定的相当大的昼夜节律和其他环境差异，在每个实验期间测试两种载体对照以及两种人参皂苷Rf施用的小鼠[2]。 |
| Data Literature Source | [1]. Nah SY，et al. A trace component of ginseng that inhibits Ca2+ channels through a pertussis toxin-sensitive G protein. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8739-43. [2]. Mogil JS，et al. Ginsenoside Rf，a trace component of ginseng root，produces antinociception in mice. Brain Res. 1998 May 11;792(2):218-28. |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO |
抑制 N 型 Ca2+ 通道。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A
Click to check >>Author：Guo S; Chen YF; Shi S; Pang CL; Wang XZ; Zhang HL;
IF：3.4000
Publish_to：Biophys J
PMID：31818463
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