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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Ginsenoside RcCAS：11021-14-0
Molecular Formula：C53H90O22
Molecular Weight：1079.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 11021-14-0 |
| Name | Ginsenoside Rc |
| Molecular Formula | C53H90O22 |
| Molecular Weight | 1079.28 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 234-253-5 |
| MDL | MFCD00133368 |
| SMILES | C[C@](CC/C=C(C)/C)([C@]1([H])[C@]([C@H](O)C[C@@]2([H])[C@@]3(C)CC[C@]4([H])[C@]2(C)CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C4(C)C)([H])[C@@]3(C)CC1)O[C@@H]7O[C@H](CO[C@@H]8O[C@@H](CO)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@H]7O |
| InChIKey | JDCPEKQWFDWQLI-LUQKBWBOSA-N |
| InChI | InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28-,29+,30-,31+,32-,33-,34+,35+,36-,37+,38-,39-,40-,41+,42+,43+,44+,45+,46-,47-,48-,50-,51+,52+,53-/m0/s1 |
| PubChem CID | 12855889 |
| Target Point | GABA Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Ginsenoside Rc potentiates GABA receptor A (GABAA)-mediated ion channel (IGABA). Ginsenoside Rc also inhibits TNF-α and IL-1β expression. |
| Biological Activity | Ginsenoside Rc 是主要的人参皂甙之一，Ginsenoside Rc 增强 GABA 受体 A (GABAA) 介导的离子通道 (IGABA)。 Ginsenoside Rc 还抑制 TNF-α 和 IL-1β 表达。[1-2] |
| In Vitro | 人参皂苷Rc是人参的主要人参皂甙之一，可增强γ-氨基丁酸(GABA)受体A(GABAA)介导的离子通道电流。人参皂苷Rc增强GABA介导的表达GABAA受体的卵母细胞中的离子电流[1]。人参皂甙Rc显著抑制巨噬细胞衍生的细胞因子如TNF-α和IL-1β的表达。人参皂苷Rc还显著抑制活化的RAW264.7巨噬细胞，人滑膜细胞和HEK293细胞中TANK结合激酶1 /IκB激酶ε/干扰素调节因子-3和p38/ATF-2信号传导的激活。人参皂苷Rc通过抑制TANK结合激酶1 /IκB激酶ε/干扰素调节因子-3和p38/ATF-2信号传导而发挥其抗炎作用。人参皂苷Rc抑制磷酸-ATF-2和磷酸-FRA-1的核转位，而p65在其峰值时间点(30和60分钟)的易位不会通过人参皂苷Rc处理而降低。人参皂甙Rc通过抑制AP-1活化来调节由巨噬细胞产生的促炎细胞因子TNF-α的表达[2]。 |
| Kinase Experiment | 为了评价人参皂苷Rc对激酶活性的影响，在存在或不存在人参皂苷Rc的情况下，将免疫沉淀的TBK1，IKKε和p38在反应缓冲液中温育。通过添加Mg-ATP引发反应。在30℃温育30分钟后，通过加入样品缓冲液终止反应并将样品煮沸。通过用针对IKKε，IRF-3和ATF-2的磷酸形式的抗体进行免疫印迹来评估激酶活性[2]。 |
| Data Literature Source | [1]. Lee BH，et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60. [2]. Yu T，et al. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-bindingkinase 1/interferon regulatory factor-3 and p38/ATF-2. J Ginseng Res. 2017 Apr;41(2):127-133. |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO |
Ginsenoside Rc 增强 GABA 受体 A (GABAA) 介导的离子通道 (IGABA)。 Ginsenoside Rc 还抑制 TNF-α 和 IL-1β 表达。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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