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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > GeniposideCAS：24512-63-8
Molecular Formula：C17H24O10
Molecular Weight：388.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 24512-63-8 |
| Name | Geniposide |
| Molecular Formula | C17H24O10 |
| Molecular Weight | 388.37 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16036219 |
| SMILES | O[C@@H]1[C@@H](CO)O[C@@H](O[C@H]2[C@@]3([H])[C@@](CC=C3CO)([H])C(C(OC)=O)=CO2)[C@H](O)[C@H]1O |
| InChIKey | IBFYXTRXDNAPMM-BVTMAQQCSA-N |
| InChI | InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1 |
| PubChem CID | 107848 |
| Target Point | Others |
| Passage | Others |
| Background | It is an iridoid glycoside with various biological activities. |
| Biological Activity | Geniposide具有多种生物活性，例如抗糖尿病，抗氧化，抗增殖和神经保护活性。[1-4] |
| In Vitro | 栀子苷具有多种活性，如抗血栓形成，抗炎，抗糖尿病，抗动脉粥样硬化，抗抑郁，治愈阿尔茨海默病(AD)，抗高血压，毒理学和不良反应等[1]。栀子苷显着降低OGD诱导的脑微血管内皮细胞中IL-8，IL-1β和MCP-1的产生，P2Y14受体的表达显着下调，RAF-1，MEK1 / 2，ERK1 /的磷酸化2被抑制[2]。 |
| In Vivo | 栀子苷(200和400mg / kg)以剂量依赖性方式显着降低糖尿病小鼠的血糖，胰岛素和TG水平。该化合物还可降低GP和G6Pase在mRNA和免疫反应蛋白水平以及酶活性中的表达[3]。栀子苷(20.0，40.0或80 mg / kg)显着逆转了过量的酒精诱导的血清ALT / AST和肝LPO水平的升高。栀子苷上调血红素加氧酶-1(HO-1)的表达，减轻盐酸3-吗啉代嘧啶亚胺(SIN-1)诱导的原代培养海马神经元细胞凋亡[4]。栀子苷抑制体内光化学诱导的血栓栓塞模型。栀子苷通过中断IκB降解是非常有效的NF-κB抑制剂[1]。 |
| Cell Experiment | 脑微血管内皮细胞(BMEC)的第三代用于实验。 BMEC分为四组：(1)正常对照组：未经处理的正常培养BMEC;(2)OGD组：按照上述方法由OGD伤害的BMEC;(3)栀子苷组：用33.2μg/ mL栀子苷处理OgD损伤的BMECs 6小时;(4)PTX组：OGD损伤的BMEC用100ng / mL PTX给药。 PTX，被称为Gi偶联受体的抑制剂，用于评估OGD诱导的P2Y14受体的激活[2]。 |
| Animal Experiment | 小鼠：通过高脂饮食和链脲佐菌素注射诱导的2型糖尿病小鼠用或不用栀子苷处理2周。通过血糖仪监测血糖水平。通过ELISA方法分析胰岛素浓度。使用Labassay试剂盒测量总胆固醇(TC)和甘油三酯(TG)水平。通过葡萄糖-6-磷酸脱氢酶偶联反应测量肝GP和G6Pase的活性。实时RT-PCR和Western印迹用于确定两种酶的mRNA和蛋白质水平[3]。 |
| Data Literature Source | [1]. Liu H， et al. Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry， pharmacology ofcardiovascular， and safety with the perspective of new drugs development. J Asian Nat Prod Res. 2013; 15 (1) :94-110. [2]. Li F， et al. Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells. J Ethnopharmacol. 2016 Jun 5; 185:77-86. [3]. Wu SY， et al. Effect of geniposide， a hypoglycemic glucoside， on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin. 2009 Feb; 30 (2) :202-8. [4]. Wang J， et al. Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes. Can J Physiol Pharmacol. 2015 Apr; 93 (4) :261-7. |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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