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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > GenipinCAS：6902-77-8
Molecular Formula：C11H14O5
Molecular Weight：226.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 6902-77-8 |
| Name | Genipin |
| Molecular Formula | C11H14O5 |
| Molecular Weight | 226.23 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 300-006-4 |
| MDL | MFCD00888600 |
| SMILES | O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC |
| InChIKey | AZKVWQKMDGGDSV-BCMRRPTOSA-N |
| InChI | InChI=1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1 |
| PubChem CID | 442424 |
| Target Point | Others |
| Passage | Others |
| Background | Genipin is an active glycoside derived from Geniposide of iridoid glycosides， which has a variety of biological activities， such as protein regulation， anti-tumor， anti-inflammation， immunosuppressive， anti-thrombotic and protection of hippocampal neurons. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin can also be used in type 2 diabetes research. |
| In Vitro | 京尼平以时间和剂量依赖性方式刺激葡萄糖摄取。在2小时时达到最大效果，浓度为10μM。在肌管中，京尼平促进葡萄糖转运蛋白4(GLUT4)易位至细胞表面，这增加了胰岛素受体底物-1(IRS-1)，AKT和GSK3β的磷酸化。同时，京尼平增加ATP水平，关闭KATP通道，然后增加C2C12肌管细胞质中钙的浓度。可以通过PI3-K抑制剂渥曼青霉素和钙螯合剂EGTA阻断京尼平刺激的葡萄糖摄取。此外，京尼平增加了C2C12肌管中活性氧和ATP的水平[1]。京尼平增加线粒体膜电位，然后增加ATP水平并关闭KATP通道，从而刺激胰腺β细胞中的胰岛素分泌。京尼平激活葡萄糖激发的POMC神经元[2]。细胞色素c含量在京尼平处理的FaO细胞的胞质溶胶中显著增加。半胱天冬酶-3和半胱天冬酶-7的激活最终导致肝细胞因子诱导的肝细胞瘤细胞凋亡过程。用200μM京尼平处理的Hep3B细胞中ROS水平显著增加[3]。 |
| Kinase Experiment | 简言之，将肽底物N-乙酰基-Asp-Glu-Val-Asp-ρ-硝基苯胺(Ac-DEVD-ρNA)加入到测定缓冲液(50mM HEPES，pH 7.4，100mM NaCl，0.1％)中的细胞裂解液中。 CHAPS，10mM二硫苏糖醇，1mM EDTA，10％甘油)并在37℃下孵育。在405nm处监测底物的裂解。 |
| Data Literature Source | [1]. Ma C，et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20. [2]. Parton LE，et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007 Sep 13;449(7159):228-32. [3]. Kim BC，et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70(9):1398-407. [4]. Ye D，et al. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. 2018 Mar 9:1-22 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg 100mg 500mg |
是环烯醚萜苷类Geniposide衍生的活性糖苷配基，具有多种生物活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage
Click to check >>Author：Tu T; Yin S; Pang J; Zhang X; Zhang L; Zhang Y; Xi
IF：4.8000
Publish_to：Front Aging Neurosci
PMID：33613273
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