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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > (-)-Epigallocatechin GallateCAS：989-51-5
Molecular Formula：C22H18O11
Molecular Weight：458.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 989-51-5 |
| Name | (-)-Epigallocatechin Gallate |
| Molecular Formula | C22H18O11 |
| Molecular Weight | 458.38 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 479-560-7 |
| MDL | MFCD00075940 |
| SMILES | O=C(O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4 |
| InChIKey | WMBWREPUVVBILR-WIYYLYMNSA-N |
| InChI | InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1 |
| PubChem CID | 65064 |
| Target Point | Autophagy |
| Passage | Metabolic Enzyme/Protease |
| Background | It is a polyphenol flavonoid that inhibits the activation of EGFR, HER2 and HER3 with antitumor activity. |
| Biological Activity | (-)-Epigallocatechin Gallate 是一种天然的多酚黄酮类化合物，能够抑制 EGFR，HER2 和 HER3 的活化，具有抗肿瘤活性。[1-3] |
| In Vitro | (-)- 表没食子儿茶素没食子酸酯(EGCG)抑制SW837人结肠癌细胞系中的活化EGFR，HER2和HER3。(-)- 表没食子儿茶素没食子酸酯(10μM)也抑制细胞生长，抑制EGFR，HER2和HER3的活化，并导致COX-2和Bcl-xL蛋白水平降低，以及治疗96 h后细胞凋亡[1] ]。(-)- 表没食子儿茶素没食子酸酯(0-35μg/ mL)抑制结肠直肠癌细胞的增殖。(-)- 表没食子儿茶素没食子酸酯(35μg/ mL)诱导结直肠癌细胞凋亡[2]。(-)- 表没食子儿茶素没食子酸酯(EGCG; 50，75和100μM)剂量依赖性地抑制HepG2细胞的生长，并诱导HepG2细胞凋亡[3]。 |
| In Vivo | (-)- 表没食子儿茶素没食子酸酯(5，10和20 mg / kg，po)抑制小鼠原位结直肠癌细胞的生长[2]。 |
| Cell Experiment | 将LoVo，SW480，HCT-8和HT-29细胞以5×103细胞的浓度接种于96孔板中; 每个细胞系完全接种在12个孔中。向孔中加入完全培养基，最高200μL; 培养基含有0μg/ mL，10μg/ mL，20μg/ mL和35μg/ mL(-)- 表没食子儿茶素没食子酸酯。抑制率= [1 -((-)- 表没食子儿茶素没食子酸酯基团的吸光度 - 对照组的吸光度)/(对照组的吸光度 - 空白对照组的吸光度)]×100 [2]。 |
| Animal Experiment | 小鼠[2]术后2周，40只裸鼠中有39只出现肿瘤。根据肿瘤体积，将39只肿瘤小鼠分为4组：对照组(n = 9); 接受5mg / kg(-)- 表没食子儿茶素没食子酸酯(n = 10)的组; 接受10mg / kg(-)- 表没食子儿茶素没食子酸酯(n = 10)的组; 和接受20mg / kg(-)- 表没食子儿茶素没食子酸酯(n = 10)的组。在治疗组中，(-)- 表没食子儿茶素没食子酸酯通过胃内给药，并且在对照组中，100μL生理盐水通过胃内给药，每天一次，持续14天。用(-)- 表没食子儿茶素没食子酸酯处理小鼠4周后，使用荧光成像系统连续监测原发性肿瘤的生长和转移。 4周后，称重原发肿瘤并立即放入液氮(-196℃)中，2至3小时后，将这些样品保存在-80℃。此外，原发肿瘤和转移瘤的其他部位固定在4％甲醛中[2]。 |
| Data Literature Source | [1]. De Amicis F， et al. Epigallocatechin gallate inhibits growth and Epithelial-to-Mesenchymal Transition in human thyroid carcinoma cell lines. J Cell Physiol. 2013 Apr 1. [2]. Jin H， et al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013; 6:145-53. [3]. Wing Pui Tsang， et al. Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. The Journal of Nutritional Biochemistry. 2010， 21 (2) : 140-146 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
是一种多酚黄酮类化合物，能够抑制 EGFR，HER2 和 HER3 的活化，具有抗肿瘤活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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