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My CartCAS：103060-53-3
Molecular Formula：C72H101N17O26
Molecular Weight：1620.67
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：Light yellow to yellow Solid
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| CAS | 103060-53-3 |
| Name | Daptomycin |
| Molecular Formula | C72H101N17O26 |
| Molecular Weight | 1620.67 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥97% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 600-389-2 |
| MDL | MFCD08282794 |
| SMILES | O=C(N[C@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@@H](C(N[C@H]1CC(O)=O)=O)C)=O)([H])CC(O)=O)=O)CCCN)=O)=O)[C@H](OC([C@](NC([C@](NC([C@@](NC(CNC1=O)=O)([H])CO)=O)([H])[C@H](C)CC(O)=O)=O)([H])CC(C(C=CC=C2)=C2N)=O)=O)C)=O)=O)[C@@H](NC(CCCCCCCCC)=O)CC3=CNC4=CC=CC=C34 |
| InChIKey | DOAKLVKFURWEDJ-RWDRXURGSA-N |
| InChI | InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1 |
| PubChem CID | 16134395 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is a cyclic lipopeptide antibiotic, which mainly has a strong bacteriostatic effect on Gram-positive cocci. It achieves antibacterial effects by destroying the function of bacterial cell membranes in many ways, including disrupting the transport of amino acids by the cell membrane, thereby hindering bacterial cell wall peptides. Biosynthesis of glycans and muramates, altering cell membrane potential. |
| Biological Activity | Daptomycin 是一种脂肽类抗生素，具有体外快速杀除革兰氏阳性细菌的活性。[1-3] |
| In Vitro | 达托霉素对萘夫西林敏感和耐药性葡萄球菌(MIC90小于或等于0.5 mg/L)和针对肠球菌(MIC90小于或等于2.0 mg/L)具有出色的体外抑制和杀菌活性。对于大多数分离的测试，达托霉素比万古霉素更有活性。除甲氧苄氨嘧啶 - 磺胺甲恶唑外，达托霉素是体外抗肠球菌最活跃的药物，对抗耐萘夫西林的葡萄球菌最活跃。当接种物从105 cfu/mL增加到107 cfu/mL时，达托霉素和万古霉素的MIC显著增加[1]。达托霉素在非常窄的药物浓度范围内(0.125至2.0 tLg/mL)有效，并且比其他针对粪链球菌的药物更具活性[2]。达托霉素抑制这些核苷酸连接的中间体的形成[3]。 |
| In Vivo | 在每天两次给予10mg/kg的剂量时，与开始治疗后48小时内感染的未治疗对照相比，达托霉素显著减少了每个肾脏的生物体数量。每天给药一次20 mg/kg，达托霉素效果较差，但治疗4天后显著减少菌落数，其活性与万古霉素或万古霉素 - 庆大霉素相当，每日两次[2]。 |
| Animal Experiment | 从18小时脑心浸液肉汤培养物制备含有109CFU/mL的接种物。随后通过标准的连续10倍稀释琼脂倾注平板技术测定每个接种物中的确切数量。用1.0-mL接种物静脉内攻击动物。已知该接种物感染正常大鼠的肾髓质。 24小时后，将动物分成8组，仅给予生理盐水(对照组)或用达托霉素10mg/kg(达托霉素10)，达托霉素20mg/kg(达托霉素20)，达托霉素10加庆大霉素开始抗生素治疗。 1.5mg/kg，20mg/kg的万古霉素，20mg/kg的万古霉素加1.5mg/kg的庆大霉素，每次注射30mg的氨苄青霉素，以及每只大鼠30mg的氨苄西林和1.5mg/kg的庆大霉素。动物每天一次接受达托霉素20;所有其他药物每天服用两次。皮下注射万古霉素和达托霉素;肌肉注射氨苄青霉素和庆大霉素。药物最多可使用13天。 |
| Data Literature Source | [1]. Benson CA，et al. Comparative in-vitro activity of LY146032 a new peptolide，with vancomycin and eight other agents against gram-positive organisms. J Antimicrob Chemother. 1987 Aug;20(2):191-6. [2]. Miniter PM，et al. Activity of LY146032 in vitro and in experimental enterococcal pyelonephritis. Antimicrob Agents Chemother. 1987 Aug;31(8):1199-203. [3]. Allen NE，et al. Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032. Antimicrob Agents Chemother. 1987 Jul;31(7):1093-9. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 10mM*1mL in Water 50mg |
是一种环酯肽类抗生素，主要对革兰阳性球菌有很强的抑菌作用，通过多方面破坏细菌细胞膜的功能，达到抗菌的作用，包括扰乱细胞膜对氨基酸的转运，从而阻碍细菌细胞壁肽聚糖和胞壁酸酯的生物合成，改变细胞膜电位。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Antibiotic-affinity chromatographic test strip for quantitative analysis and antibiotic resistance testing of Staphylococcus aureus
Click to check >>Author：Shi Y. Yang H. He Y. Fu Z
IF：12.5820
Publish_to：Talanta
PMID：31450481
Antibiotic-affinity chromatographic test strip for quantitative analysis and antibiotic resistance testing of Staphylococcus aureus.
Click to check >>Author：Shi Y; Yang H; He Y; Fu Z.
IF：5.7560
Publish_to：Talanta
PMID：31450481
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