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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Bacterial > Clindamycin HydrochlorideCAS：21462-39-5
Molecular Formula：C18H34Cl2N2O5S
Molecular Weight：461.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 21462-39-5 |
| Name | Clindamycin Hydrochloride |
| Molecular Formula | C18H34Cl2N2O5S |
| Molecular Weight | 461.44 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-398-6 |
| MDL | MFCD07793327 |
| SMILES | C[C@H](Cl)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl |
| InChIKey | AUODDLQVRAJAJM-XJQDNNTCSA-N |
| InChI | InChI=1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1 |
| PubChem CID | 16051951 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Clindamycin Hydrochloride is a lincosamide antibiotic that inhibits protein synthesis by acting on the 50S ribosomal. |
| Biological Activity | Clindamycin hydrochloride 是一种半合成的林可胺类抗生素，通过作用于 50S ribosomal 来抑制蛋白质的合成。[1-4] |
| In Vitro | 克林霉素是细菌蛋白质合成的经典抑制剂，通过与50S核糖体亚基的23S核糖体RNA结合[1]。 |
| In Vivo | 克林霉素盐酸盐在狗口服给药后快速吸收，平均吸收时间(MAT)为0.87小时，生物利用度为72.55％。在口服给药(0.503对0.458L/h/kg)后，克林霉素盐酸盐导致克林霉素的总清除率(CL)。克林霉素盐酸盐在稳态(IV)下的体积分布为2.48L/kg，表明克林霉素在体液和组织中的分布广泛。静脉注射和口服给药后克林霉素血清浓度大约保持在0.5μg/ mL以上，持续10小时[1]。克林霉素盐酸盐显著降低狗的基线水平42天的口腔恶臭。克林霉素盐酸盐还可导致狗牙菌斑，牙结石和牙龈出血的显著减少[2]。超声波结垢，根面刨削和抛光(USRP)后，盐酸克林霉素(2.5 mg/Lb)对牙周病的牙菌斑和口袋深度测量有显著影响，但对犬的牙龈炎没有影响[3]。在14至28天内治疗后，盐酸克林霉素导致犬浅表性细菌性脓皮病犬的完全缓解率为71.4％(15/21)[4]。 |
| Animal Experiment | 对于第一个实验期，在左侧头静脉导管插入后，向所有动物静脉内施用11mg/kg BW克林霉素盐酸盐(第0天)。在给药后不久取出导管(18G×51mm Abbocath-T)。在(t = 0h)和2，5，10，15，20，30，45分钟，1，1.5，2之前，通过从导管插入的侧头静脉抽吸将血样(3mL)收集到塑料管中。给药后2.5，2，4，5，6，8，10，12和24小时。每次取样后，用2mL 1％肝素化生理盐水冲洗静脉内导管。在第28天，所有狗都接受一个Antirobe胶囊(150mg克林霉素盐酸盐)。通过将接受的克林霉素的总量除以其体重，在每只动物中进行从mg /动物到mg/kg BW的剂量标准化。按照上述技术，在紧接之前(t = 0h)和15，30，45分钟，1，1.5，2，2.5，3，4，5，6，8，10，12进行血样采集。药物给药后24小时。将所有血液样品在暗处静置20分钟。在4℃下以1500g离心10分钟后，将上清液转移到5-mL塑料管中并储存在-30℃，等待分析。 |
| Data Literature Source | [1]. Batzias GC，et al. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005 Nov;170(3):339-45. [2]. Warrick JM，et al. Effect of clindamycin hydrochloride on oral malodor，plaque，calculus，and gingivitis in dogs with periodontitis. Vet Ther. 2000 Winter;1(1):5-16. [3]. Nielsen D，et al. Effects of treatment with clindamycin hydrochloride on progression of canine periodontal disease after ultrasonic scaling. Vet Ther. 2000 Summer;1(3):150-8. [4]. Bloom PB，et al. Efficacy of once-daily clindamycin hydrochloride in the treatment of superficial bacterial pyoderma in dogs. J Am Anim Hosp Assoc. 2001 Nov-Dec;37(6):537-42 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO |
是一种林可胺类抗生素，通过作用于 50S ribosomal 来抑制蛋白质的合成。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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