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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Baohuoside ICAS：113558-15-9
Molecular Formula：C27H30O10
Molecular Weight：514.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 113558-15-9 |
| Name | Baohuoside I |
| Molecular Formula | C27H30O10 |
| Molecular Weight | 514.52 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD15071140 |
| InChIKey | NGMYNFJANBHLKA-LVKFHIPRSA-N |
| InChI | InChI=1S/C27H30O10/c1-12(2)5-10-16-17(28)11-18(29)19-21(31)26(37-27-23(33)22(32)20(30)13(3)35-27)24(36-25(16)19)14-6-8-15(34-4)9-7-14/h5-9,11,13,20,22-23,27-30,32-33H,10H2,1-4H3/t13-,20-,22+,23+,27-/m0/s1 |
| PubChem CID | 5488822 |
| Target Point | CXCR |
| Passage | Immunology & Inflammation;GPCR & G Protein |
| Background | Baohuoside I, a flavonoid, is an inhibitor of CXCR4. |
| Biological Activity | Baohuoside I 是从朝鲜淫羊藿中得到的黄酮类化合物，作为 CXCR4 的抑制剂，能够抑制 CXCR4 的表达，诱导凋亡，具有抗肿瘤活性。[1-3] |
| In Vitro | 宝霍赛德I是CXCR4的抑制剂，并在12-25μM下调CXCR4表达。宝霍赛德I(0-25μM)以剂量依赖性方式抑制NF-κB活化，抑制CXCL12诱导宫颈癌细胞的侵袭。宝霍赛德我也抑制乳腺癌细胞的侵袭[1]。宝霍赛德I抑制A549细胞活力，24小时，11.5μM和9.6μM的48小时和72小时的IC50分别为25.1μM。宝霍赛德I((25μM)抑制A549细胞中的caspase级联，提高ROS水平并激活JNK和p38MAPK信号级联反应[2]。宝霍赛德I(3.125，6.25，12.5，25.0和50.0μg/ mL)显著且剂量依赖性阻断食管鳞状细胞癌Eca109细胞的生长，48小时IC50为4.8μg/ mL [3]。 |
| In Vivo | 宝霍赛德I(25 mg/kg)可降低裸鼠体内β-catenin蛋白水平，cyclin D1和survivin的表达[3]。 |
| Cell Experiment | 通过MTT测定法测定了宝霍赛德I对A549细胞的细胞毒作用。将细胞(1×10 4个细胞/孔)接种在96孔板中，并用宝华苷I(6.25，12.5和25μM)或1mM NAC处理24，48或72小时。除去含MTT的培养基后，通过向每个孔中加入DMSO溶解已形成的晶体。混合后，使用Multiskan Spectrum Microplate Reader [2]在540 nm处测量细胞的吸光度。 |
| Animal Experiment | 小鼠[3]雌性Balb/c裸鼠(4-6周龄)用于测定。收获亚汇合的Eca109-Luc细胞并重悬于PBS中至最终密度为2×10 7个细胞/ mL。在注射之前，将细胞重悬于PBS中并通过0.4％台盼蓝排除测定法(活细胞> 90％)进行分析。对于皮下注射，使用27G针将200μLPBS中的1×107个Eca109-Luc细胞注射到每只小鼠的左侧腹中。在肿瘤细胞注射后1周，每天一次在病灶内注射宝霍赛德I(每只小鼠25mg/kg)，而用于载体治疗的10只小鼠给予等体积的PBS [3]。 |
| Data Literature Source | [1]. Kim B，et al. Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. Biochemistry. 2014 Dec 9;53(48):7562-9. [2]. Song J，et al. Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. Chem Biol Interact. 2012 Jul 30;199(1):9-17. [3]. Wang L，et al. The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling. Oncol Rep. 2011 Nov;26(5):1149-56. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Baohuoside I 是一种黄酮类化合物，是 CXCR4 的抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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