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My CartCAS：71751-41-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 71751-41-2 |
| Name | Avermectin |
| Molecular Formula | B1a:C48H72O14;B1b:C47H70O14 |
| Molecular Weight | B1a:873.09;B1b:859.06 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-096-6 |
| MDL | MFCD01769550 |
| SMILES | C[C@@H](CC)[C@]1([H])[C@@H](C)C=C[C@@]2(O[C@@]3([H])C[C@]([H])(OC([C@@]4([H])[C@@](/C(CO5)=C/C=C/[C@H](C)[C@H](O[C@@]6([H])C[C@H](OC)[C@@H](O[C@]7([H])O[C@@H](C)[C@H](O)[C@@H](OC)C7)[C@H](C)O6)/C(C)=C/C3)(O)[C@@]5([H])[C@H](O)C(C)=C4)=O)C2)O1.C[C@H]8C=C[C@@]9(O[C@@]%10([H])C[C@]([H])(OC([C@@]%11([H])[C@@](/C(CO%12)=C/C=C/[C@H](C)[C@H](O[C@@]%13([H])C[C@H](OC)[C@@H](O[C@]%14([H])O[C@@H](C)[C@H](O)[C@@H](OC)C%14)[C@H](C)O%13)/C(C)=C/C%10)(O)[C@@]%12([H])[C@H](O)C(C)=C%11)=O)C9)O[C@@H]8C(C)C |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | It is a 16-membered macrolide compound with insecticidal, acaricidal and nematicidal activities. |
| Biological Activity | Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy[1-4]. |
| In Vitro | Avermectin B1(0-80 μM，12 h)induces cytotoxicity through MAPK and ATM/ATR pathway in mouse embryonic fibroblast(MEF)cells，and induces ROS-mediated DNA damage[1].Avermectin B1(36 μg/mL，72 h)has strong nematicidal efect of on G. pallida in aqueous solution，and negatively influences viability and infectivity of G. pallida J2 detected in potato roots(cv. Spunta)[2].Abamectin(10 μM，24 h)induces significant cytotoxicity by overproduction of ROS in haemocytes of Erocheir sinensis[3].Abamectin(4 μM，24 h)induces apoptosis and autophagy by inhibiting ROS-mediated PI3K/AKT signaling in MGC803 cells[4]. |
| Data Literature Source | [1]. [1] Yiran Liang，et al. Abamectin induces cytotoxicity via the ROS，JNK，and ATM/ATR pathways. PLoS One. Environ Sci Pollut Res Int. 2020 Apr;27(12):13726-13734. [2]. Nicola Sasanelli，et al. Abamectin Efficacy on the Potato Cyst Nematode Globodera pallida. Plants (Basel). 2019 Dec 19;9(1):12. [3]. Yi Huang，et al. Cytotoxicity induced by abamectin exposure in haemocytes of Chinese mitten crab，Eriocheir sinensis. Environ Toxicol Pharmacol. 2020 Jul;77:103384. [4]. Shanshan Zhu，et al. Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species-mediated PI3K/AKT signaling in MGC803 cells. J Biochem Mol Toxicol. 2019 Jul;33(7):e22336. |
| Unit | Bottle |
| Specification | 100mg 200mg |
是一类具有杀虫、杀螨、杀线虫活性的十六元大环内酯化合物。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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