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My CartCAS：73030-71-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 73030-71-4 |
| Name | Atractylenolide III |
| Molecular Formula | C15H20O3 |
| Molecular Weight | 248.32 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00238543 |
| SMILES | O=C1C(C)=C(C[C@@]23[H])[C@@](C[C@@]3(C)CCCC2=C)(O)O1 |
| InChIKey | FBMORZZOJSDNRQ-GLQYFDAESA-N |
| InChI | InChI=1S/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1 |
| PubChem CID | 155948 |
| Target Point | Apoptosis |
| Passage | Apoptosis |
| Background | Atractylenolide III has been reported to induce apoptosis in lung cancer cells by inducing cytochrome c release, upregulating Bax expression, and translocation apoptosis-inducing factors. |
| Biological Activity | Atractylenolide III was the major gastroprotective component of A. ovata in ethanol-induced acute gastric ulcer. It is suggested that the gastroprotective mechanism of atractylenolide III was via inhibition of the MMP-2 and MMP-9 pathway.[1] |
| In Vitro | ATL-III inhibited cell growth，increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c，upregulation of bax expression，and translocation of apoptosis-inducing factor. In addition，ATL-III inhibited the proliferation and capillary tube formation of human umbilical vein endothelial cells.[2] |
| In Vivo | Oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.34 mm. In the in-vivo assay，atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase(MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues.[1] |
| Animal Experiment | Five sesquiterpenoids(atractylon，atractylenolides I，II，III and biatractylolide)were isolated from the extracts of A. ovata rhizome via silica gel column chromatography. The gastroprotective effects of these five sesquiterpenoids were measured in in-vitro ethanol-induced primary culture rat gastric mucosal(PRGM)cell damage and in-vivo ethanol-induced acute rat gastric ulcer models.[1] |
| Data Literature Source | [1]. Wang KT，Chen LG，Wu CH，Chang CC，Wang CC. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo. J Pharm Pharmacol. 2010 Mar;62(3):381-8. [2]. Kang TH，Bang JY，Kim MH，Kang IC，Kim HM，Jeong HJ. Atractylenolide III，a sesquiterpenoid，induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway. Food Chem Toxicol. 2011 Feb;49(2):514-9. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
有诱导肺癌细胞凋亡活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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产品用什么稀释呢？稀释以后也是需要放在-20度储存吗？ 2022-07-26 20:02:34
Administrator稀释需要根据您具体的实验需求进行选择，一般常用的有培养基、缓冲液、生理盐水、灭菌水等。
稀释后的工作液建议现配现用。