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My CartCAS：73069-14-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 73069-14-4 |
| Name | Atractylenolide II |
| Molecular Formula | C15H20O2 |
| Molecular Weight | 232.32 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00013986 |
| SMILES | O=C1C(C)=C(C[C@@]23[H])[C@@](C[C@@]3(C)CCCC2=C)([H])O1 |
| InChIKey | OQYBLUDOOFOBPO-KCQAQPDRSA-N |
| InChI | InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h12-13H,1,4-8H2,2-3H3/t12-,13-,15+/m0/s1 |
| PubChem CID | 14448070 |
| Target Point | Others |
| Passage | Others |
| Background | Atractylenolide II is a sesquiterpenoid with antiproliferative activity. |
| Biological Activity | Atractylenolide II (AT-II) is a sesquiterpene compound isolated from the dried rhizome of Atractylodes macrocephala (Baizhu in Chinese), which is traditionally prescribed for melanoma treatment by Chinese medicine practitioners. AT-II can inhibit B16 cells proliferation.[1] |
| In Vitro | AT-II treatment for 48 h dose-dependently inhibited cell proliferation with an IC(50)of 82.3 μM，and induced G1 phase cell cycle arrest. Moreover，treatment with 75 μM AT-II induced apoptosis. These observations were associated with the decrease of the expression of Cdk2，phosphorylated-Akt，phosphorylated-ERK and Bcl-2，the increase of the expression of phosphorylated-p38，phosphorylated-p53，p21，p27，and activation of caspases-8，-9 and -3. In addition，a chemical inhibitor of p53，PFTα，significantly decreased AT-II-mediated growth inhibition and apoptosis.The G1-arresting and apoptotic effects of AT-II in B16 cells involve p38 activation as well as ERK and Akt inactivation，and the cytotoxic/apoptotic effects of AT-II are potentially p53 dependent. [1] |
| Data Literature Source | [1]. Ye Y，Wang H，Chu JH，Chou GX，Chen SB，Mo H，Fong WF，Yu ZL. Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells. J Ethnopharmacol. 2011 Jun 14;136(1):279-82. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
是一种倍半萜类化合物，具有抗增殖活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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