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My CartCAS：480-10-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 480-10-4 |
| Name | Astragalin |
| Molecular Formula | C21H20O11 |
| Molecular Weight | 448.38 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00075932 |
| SMILES | OC1=CC2=C(C(C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C(C4=CC=C(O)C=C4)O2)=O)C(O)=C1 |
| InChIKey | JPUKWEQWGBDDQB-QSOFNFLRSA-N |
| InChI | InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1 |
| PubChem CID | 5282102 |
| Target Point | Others |
| Passage | Others |
| Background | Astragalin is a flavonoid with anti-inflammatory， antioxidant， anticancer and antibacterial activities. Astragalin has been reported to inhibit the proliferation and migration of cancer cells and induce apoptosis. |
| Biological Activity | Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds. Astragalin may be a potent agent antagonizing endotoxin-induced oxidative stress leading to airway dysfunction and inflammation.[1] |
| In Vitro | When airway epithelial cells were exposed to 2 μg/ml LPS，astragalin nontoxic at ≤ 20 μM suppressed cellular induction of Toll-like receptor 4(TLR4)and ROS production enhanced by LPS. Both LPS and H2O2 induced epithelial eotaxin-1 expression，which was blocked by astragalin. LPS activated and induced PLCγ1，PKCβ2，and NADPH oxidase subunits of p22phox and p47phox in epithelial cells and such activation and induction were demoted by astragalin or TLR4 inhibition antagonizing eotaxin-1 induction. H2O2-upregulated phosphorylation of JNK and p38 MAPK was dampened by adding astragalin to epithelial cells，while this compound enhanced epithelial activation of Akt and ERK. H2O2 and LPS promoted epithelial apoptosis concomitant with nuclear condensation or caspase-3 activation，which was blunted by astragalin.Astragalin ameliorated oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling.[1] |
| Cell Experiment | Airway epithelial BEAS-2B cells were exposed to lipopolysaccharide(LPS)in the absence and presence of 1-20 μM astragalin.[1] |
| Data Literature Source | [1]. Cho IH，et al. Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling. BMC Pulm Med. 2014 Jul 29;14:122. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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