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My CartCAS：497-76-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 497-76-7 |
| Name | Arbutin |
| Molecular Formula | C12H16O7 |
| Molecular Weight | 272.25 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-850-3 |
| MDL | MFCD00016915 |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(O)C=C2 |
| InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| InChI | InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1 |
| PubChem CID | 440936 |
| Target Point | Tyrosinase |
| Passage | Metabolic Enzyme&Protease |
| Background | Arbutin is a glycoside that inhibits tyrosinase, preventing melanin production. |
| Biological Activity | Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[1-3]. |
| In Vitro | Arbutin(0.3-5.4 mM; 24 hours，48 hours，72 hours; B16 murine melanoma cells)inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner.Arbutin(1.4-5.4 mM; 24 hours)increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM[2]. |
| In Vivo | Arbutin(50 mg/kg，100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice)pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice[3]. |
| Data Literature Source | [1]. Garcia-Jimenez A，et al. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330. [2]. Jiang L，et al. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murinemelanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054. [3]. Nalban N，et al. Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. Cardiovasc Toxicol. 2019 Sep 4. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Examples of using this product（for reference only）
In Vivo:
Rat（Arbutin 50mg/kg，Oral，2/d，3d）:
Seventy rats were randomly divided into 7 groups (female and male in equal numbers for each group): control group(8, C), SCM model group (12, SCM), AI treated group (10, AI,200 mg kg?1), CY extract treated group (10, CY, 1630 mg kg?1),Ade treated group (10, Ade, 50 mg kg?1), Arb treated group (10,Arb, 50 mg kg?1) and All treated group (10, All, 50 mg kg?1).The SCM model was induced by subcutaneous injection of LPS at a dose of 10 mg kg?1. The drugs were orally administered twice a day for 3 days, respectively. The C and SCM groups were orally administered with the same volume of distilled water in the meantime. All rats were sacrificed after the detection of the cardiac function and the blood sample was obtained from the abdominal aorta.
Reference：
Zhou N, Zeng MN, Li K, Yang YY, Bai ZY, Zheng XK, Feng WS . An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy. Food Funct. 2018 Sep 19;9(9):4989-4997. doi: 10.1039/c8fo00688a. PMID: 30187904.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
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