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My CartCAS：65710-07-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥95%
Appearance：White to yellow Solid
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| CAS | 65710-07-8 |
| Name | Apramycin Sulfate |
| Molecular Formula | C21H43N5O15S |
| Molecular Weight | 637.66 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | ≥95% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 265-890-7 |
| MDL | MFCD06200257 |
| SMILES | O[C@H]1[C@](O[C@H](O[C@@]([C@H](C[C@H]2N)N)([H])[C@@H]([C@H]2O)O)[C@H](N)C3)([H])[C@@]3([H])O[C@H](O[C@@]([C@@H]([C@@H](O)[C@@H]4N)O)([H])O[C@@H]4CO)[C@H]1NC.O=S(O)(O)=O |
| InChIKey | WGLYHYWDYPSNPF-RQFIXDHTSA-N |
| InChI | InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1 |
| PubChem CID | 3081544 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Apramycin Sulfate is an orally active aminoglycoside antibiotic resistant to aminoglycoside modifying enzymes that inhibit protein biosynthesis by targeting bacterial ribosomes. |
| Biological Activity | Apramycin Sulfate (Ai3-29795)是一种氨基糖苷类抗生素，与RNA的深槽结合。[1-3] |
| In Vitro | Apramycin在农场的过度消耗非常可能驱动了[aac(3)-IV 阳性] E. coli在患病的猪和健康的屠杀整理工中出现Apramycin/Gentamicin交叉抗性的增加。[1] Apramycin抑制A. pleuropneumoniae FMV 87-682，其MIC50为8 毫克/升。Apramycin(1/4 MIC)在培养基中减少测试菌株的生长率，并且引起高达5小时的抗生素后效应(PAE)。Apramycin显著减少A. pleuropneumoniae的溶血活性，并且影响该离体的和P. multocida(类型A)的一个离体的荚膜材料生产。[2]由亮氨酸、异亮氨酸和丝氨酸的结合检测发现，Apramycin诱导翻译错误，尽管这种作用仅发生于有限的范围，在无细胞系统中，大肠埃希菌与poly(U)的程序化。Apramycin抑制体内，巨大芽孢杆菌的原生质体中，和体外，大肠杆菌无细胞系统中蛋白质合成的易位步骤。[3] |
| Data Literature Source | [1] Jensen VF，et al. J Antimicrob Chemother，2006，58(1)，101-107. [2] Diarra MS，et al. Int J Antimicrob Agents，1999，12(3)，229-237. [3] Kamei C，et al. Immunopharmacol Immunotoxicol，1992，14(1-2)，191-205. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in Water |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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