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My CartCAS：523-50-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 523-50-2 |
| Name | Angelicin |
| Molecular Formula | C11H6O3 |
| Molecular Weight | 186.16 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-480-6 |
| MDL | MFCD00064930 |
| SMILES | O=C1C=CC2=CC=C(OC=C3)C3=C2O1 |
| InChIKey | XDROKJSWHURZGO-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H |
| PubChem CID | 10658 |
| Target Point | Others |
| Passage | Others |
| Background | It is a natural tricyclic aromatic hydrocarbon compound, structurally related to psoralen, and has anti-cancer, anti-inflammatory, anti-viral and other activities. |
| Biological Activity | Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.[1-2] |
| In Vitro | Isopsoralen treatment stimulates the accumulation of cartilage nodules in a dose-dependent manner. Isopsoralen enhances the expressions of chondrogenic marker genes such as collagen II，collagen X，OCN，Smad4 and Sox9 in a time-dependent manner. Furthermore，isopsoralen induces the activation of extracellular signal-regulated kinase(ERK)and p38 MAP kinase，but not that of c-jun N-terminal kinase(JNK). Isopsoralen significantly enhances the protein expression of BMP-2 in a time-dependent manner and mediates a chondromodulating effect by BMP-2 or MAPK signaling pathways[2]. |
| In Vivo | Isopsoralen has significant osteoprotective effect in female and male mice with sex hormone deprivation. After administration of isopsoralen for 8 weeks，Bone strength increases and trabecular bone microstructure improves[1]. After intravenous administration to wistar rats，the elimination half-lives of isopsoralen is 5.35 h. The area under the curves of the tissues for isopsoralen decrease in the following order: kidney > lung > liver > heart > spleen > brain. After oral administration to Wistar rats，the elimination half-lives of isopsoralen is 5.56 h，and its bioavailability is 70.35%[3]. |
| Data Literature Source | [1] Xiaomei Yuan，et al. BioMed Research International. 2016. [2] Li L，et al. Biomol Ther (Seoul). 2012，20(3):299-305. [3] Feng L，et al. Arch Pharm Res. 2010，33(2):225-30. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
是一种天然的三环芳烃化合物，结构上跟补骨脂素有关，具有抗癌、抗炎、抗病毒等活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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