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My CartCAS：26787-78-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 26787-78-0 |
| Name | Amoxicillin |
| Molecular Formula | C16H19N3O5S |
| Molecular Weight | 365.4 |
| Solubility | Soluble in Water ≥2mg/mL;Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 248-003-8 |
| MDL | MFCD00056860 |
| SMILES | OC([C@@H]1N(C2=O)[C@]([C@@H]2NC([C@@H](C3=CC=C(O)C=C3)N)=O)([H])SC1(C)C)=O |
| InChIKey | LSQZJLSUYDQPKJ-NJBDSQKTSA-N |
| InChI | InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1 |
| PubChem CID | 33613 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Amoxicillin, a beta-lactam antibiotic, inhibits the biosynthesis of peptides in the cell wall, thereby inhibiting cell growth. |
| Biological Activity | Amoxicillin (Amoxycillin) 是一种温和β-内酰胺抗生素，用于治疗敏感菌引起的微生物细菌感染。[1-4] |
| In Vitro | Amoxicillin处理的细胞分泌大量的白细胞介素-5和大多较低或没有的肿瘤坏死因子α，白介素-4和干扰素-γ。Amoxicillin特异性T细胞克隆不能显示出药物特异性的细胞毒性，但刀豆素A的存在下杀死靶细胞，表现为细胞溶解的主要能力。[1] Amoxicillin在pH为1.0的盐酸(HCl)比在pH 7.8的磷酸盐缓冲液释放更快。在pH 1.0的盐酸介质中，Amoxicillin会在37摄氏度被降解到一定程度，这表明阿莫西林在酸性环境下是不稳定的。[2 ] Amoxicillin在小于等于8毫克/毫升时，抑制15株菌株中的4株。Amoxicillin(4毫克/毫升)与clavulanic acid(小于等于2 毫克/毫升)联用抑制15株菌株中的14株。[3] Amoxicillin抑制50％的菌株的浓度在4毫克/毫升 cefotaxime存在时从0.5毫克/毫升降低到0.06 毫克/毫升(范围为0.01至0.25毫克/毫升)。[4] |
| Data Literature Source | [1] Yawalkar N，et al. J Invest Dermatol，2000，115(4)，647-652. [2] Liu Z，et al. J Control Release，2005，102(1)，135-144. [3] Cynamon MH，et al. Antimicrob Agents Chemother，1983，24(3)，429-431. [4] Mainardi JL，et al. Antimicrob Agents Chemother，1995，39(9)，1984-1987. |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 100mg 500mg |
是中谱的β内酰胺抗菌素。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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