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My CartCAS：6018-19-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 6018-19-5 |
| Name | Sodium 4-aminosalicylate Dihydrate |
| Molecular Formula | C7H6NNaO3·2H2O |
| Molecular Weight | 211.15 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-091-2 |
| MDL | MFCD00151044 |
| SMILES | O=C(O[Na])C1=C(O)C=C(N)C=C1.O.O |
| InChIKey | GMUQJDAYXZXBOT-UHFFFAOYSA-M |
| InChI | InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1 |
| PubChem CID | 16211148 |
| Target Point | Antibiotic |
| Passage | Anti-infection |
| Background | It is an antibiotic with anti-tuberculosis activity through the inhibition of NF-κB and free radical scavenging. |
| Biological Activity | Sodium 4-Aminosalicylate是一种用于治疗肺结核的抗生素，通过NF-κB的抑制和自由基清除起作用。[1-5] |
| In Vitro | 4-Aminosalicylate与DPPH迅速反应，这表明其具有有效的自由基清除剂活性。4- Aminosalicylate表现出氢过氧自由基清除能力，由氢过氧自由基的水溶性2，2'-偶氮二-(2-脒基丙烷盐酸盐)偶氮引发剂产生，通过抑制顺式十八碳四烯酸荧光衰减或氧消耗可以证明。4-Aminosalicylate迅速清除水相中的氢过氧自由基，产生类似Trolox或半胱氨酸的的浓度依赖性周期，表明链断裂型抗氧化活性。[1] [14C]4-Aminosalicylate转化为大量代谢物，在活化的单核细胞和活化的粒细胞中，对其中的水杨酸和龙胆酸进行了表征。4-Aminosalicylate(0.65 mM)减弱超氧自由基或过氧化氢对中国仓鼠卵巢细胞的致死作用。[2]在培养的小鼠腹腔巨噬细胞中，Aminosalicylate(25 mM)通过涉及肌醇1，4，5-三磷酸产生，钙离子流，和Gi/Go的通路，以时间-和浓度依赖的方式刺激磷脂酶D。处理巨噬细胞后，4-aminosalicylate(20 mM)增加260%的肌醇1，4，5-三磷酸水平。在培养的小鼠腹腔巨噬细胞中，4-aminosalicylate(5 mM)增强蛋白激酶C对PLD的激活作用。[3]在离体的结肠粘膜细胞中，4-aminosalicylate(0.1 mM)剂量相关性减少LTB4的合成，从而减少LTB4/PGE2比率。[4]4-aminosalicylate(0.1 毫克/毫升)优先从基地外侧(BL)转运到顶端(AP)的方向，N-乙酰代谢物仅出现在AP隔间。[5] |
| In Vivo | 4-aminosalicylate(7.5 毫克/毫升，局部灌注)导致N-乙酰基-5-氨基水杨酸出现在麻醉大鼠的肠道中。[5] |
| Data Literature Source | [1] Dinis TC，et al. Arch Biochem Biophys，1994，315(1)，161-169. [2] Dull BJ，et al. Biochem Pharmacol，1987，36(15)，2467-2472. [3] Gómez-Mu oz A，et al. Biochim Biophys Acta，2001，1533(2)，110-118. [4] Schmidt C，et al. Curr Med Res Opin，1996，13(7)，417-425. [5] Zhou SY，et al. Drug Metab Dispos，1999，27(4)，479-485. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in Water 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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