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My CartCAS：546-43-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 546-43-0 |
| Name | Alantolactone |
| Molecular Formula | C15H20O2 |
| Molecular Weight | 232.32 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-899-3 |
| MDL | MFCD00046915 |
| SMILES | O=C(O[C@@]1([H])[C@]2([H])C=C3[C@@H](C)CCC[C@]3(C)C1)C2=C |
| InChIKey | PXOYOCNNSUAQNS-AGNJHWRGSA-N |
| InChI | InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1 |
| PubChem CID | 72724 |
| Target Point | STAT3 |
| Passage | JAK/STAT Signaling |
| Background | Alantolactone is a selective inhibitor of STAT3 with antitumor activity. |
| Biological Activity | Alantolactone 是 STAT3 的选择性抑制剂，并具有抗肿瘤活性[1-2]。 |
| In Vitro | Alantolactone以剂量依赖性方式诱导HepG2细胞凋亡。发现这种Alantolactone诱导的细胞凋亡与GSH耗竭，STAT3激活抑制，ROS产生，线粒体跨膜电位耗散，Bax/Bcl-2比值增加和caspase-3激活有关[1]。 Alantolactone降低STAT3易位至细胞核，其DNA结合和STAT3靶基因表达。 Alantolactone显著抑制STAT3活化，对MAPKs和NF-κB转录具有边际效应;然而，这种作用并不是通过抑制STAT3上游激酶来实现的[2]。 |
| In Vivo | 发现与对照小鼠相比，Alantolactone处理的小鼠的平均肿瘤体积约低2.17倍。然而，在实验期间给予Alantolactone不影响总体重，表明没有明显的毒性。另外，与对照小鼠相比，在Alantolactone处理的小鼠中平均肿瘤重量显著更低。此外，Alantolactone的使用导致肿瘤组织中p-STAT3和cyclin D1表达的显著降低[2]。 |
| Cell Experiment | 将细胞培养24小时，然后在96孔板中进行药物处理。用Alantolactone(0，10，20，30，40，50和60μM)处理细胞12小时，并通过MTT测定法测量细胞活力[1]。 |
| Animal Experiment | 小鼠[2]使用6周龄的雌性无胸腺BALB/c裸鼠。将MDA-MB-231细胞(5×10 6个细胞/200μL)皮下注射到小鼠的右侧腹中。注射细胞10天后，将小鼠随机分成治疗组和对照组(n = 5)。每2天给动物施用Alantolactone(2.5mg/kg体重，悬浮于DMSO 0.1％v/v，100μL腹膜内注射)，而对照动物用等体积的盐水处理[2]。 |
| Data Literature Source | [1]. Khan M，et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion，inhibition of STAT3 activation，and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858. [2]. Chun J，et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
是 STAT3 的选择性抑制剂，并具有抗肿瘤活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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