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My CartCAS：73-24-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 73-24-5 |
| Name | Adenine |
| Molecular Formula | C5H5N5 |
| Molecular Weight | 135.13 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-796-1 |
| MDL | MFCD00041790 |
| SMILES | NC1=C2N=CNC2=NC=N1 |
| InChIKey | GFFGJBXGBJISGV-UHFFFAOYSA-N |
| InChI | InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) |
| PubChem CID | 190 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | One of the four nuclear bases that make up DNA and RNA molecules, it has a variety of biochemical functions and is also involved in protein, DNA and RNA synthesis. |
| Biological Activity | Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD and FAD, and protein synthesis, as a chemical component of DNA and RNA.[1] |
| Data Literature Source | 1. Barrett C，et al. Assay Drug Dev Technol. 2006 Dec;4(6):661-9. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Examples of using this product（for reference only）
In Vivo:
Adenine?induced chronic renal failure rat model（Rat; Chronic renal failure models; 2.5% Adenine/sterile 0.9% saline solution; 200mg/kg/d, gavage, 4weeks）
Chronic renal failure models are induced by 2.5% adenine (Solarbio, Beijing, China) (200 mg/kg/d) administered by gavage for 4weeks. Adenine was dissolved in sterile 0.9% saline solution.
Reference：
Li W, Wang L, Chu X, Cui H, Bian Y. Icariin combined with human umbilical cord mesenchymal stem cells significantly improve the impaired kidney function in chronic renal failure. Mol Cell Biochem. 2017 Apr;428(1-2):203-212. doi: 10.1007/s11010-016-2930-8. Epub 2017 Jan 23. PMID: 28116543.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Li W, et al.Mol Cell Biochem. 2017 Apr;428(1-2)203-212.
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