5-Fluorouracil
Cat.No：F8300 Solarbio
CAS：51-21-8
Appearance：White Powder
Storage：Store at 2-8℃，2 years
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> Biochemical Reagents > Nucleic Acids & Nucleotides & Derivatives > 5-Fluorouracil
Product Information
| Name | 5-Fluorouracil |
| CAS | 51-21-8 |
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.08 |
| Storage | Store at 2-8℃，2 years |
| Appearance | White Powder |
| Content | 98.0-102.0% |
| Solubility | 50mg/mL 1M NaOH |
| Unit | Bottle |
| Specification | 1g |
Product introduction
5-fluorouracil, referred to as fluorouracil, is a pyrimidine antimetabolite and an antineoplastic drug. This product is only used for biochemical research.
5-fluorouracil Principle:
5-fluorouracil antineoplastic drugs are a class of broad-spectrum antineoplastic drugs that interfere with the nucleic acid metabolism of tumor cells through a variety of pathways and metabolites. The main pathways are: 5-fluorouracil is converted into 5-fluorouracil deoxynucleotide (5 F-dU old) in tumor cells, which can covalently combine with reduced tetrahydrofolate and thymidine nucleotide synthetase (TS) to form a ternary complex, which inactivates TS acid and inhibits DNA synthesis, thereby inhibiting tumor cell proliferation.
The drug is mainly specific for s phase, but after being converted to 5-fluorouracil nucleoside (5-FUR) in vivo, it can also be incorporated into RNA to interfere with protein synthesis, so it can also act on cells in other phases. As an anticancer drug, 5-fluorouracil has an inhibitory effect on a variety of tumors, but the disadvantage is that the effective dose of 5-fluorouracil is similar to the toxic dose, which kills cancer cells while causing serious damage to normal cells.
Physical properties
Reference solubility: 20mg/mlDMSO completely dissolved.
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Related Paper
Soil organic carbon changed by grazing determinates the abundance, diversity and composition of aerobic methanotroph communities in cyanobacteria-dominated biological soil crusts in desert steppes
Click to check >>Author：Xiao Yongxin, Hu Ciyin, Hsiang Tom, Li Junkai
IF：5.6000
Publish_to：Frontiers in Plant Science
PMID：37332709
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