5-Aza-2-Deoxycytidine
Cat.No：D9010 Solarbio
CAS：2353-33-5
Appearance：White Powder
Storage：Store at 2-8℃，2 years
Purity：≥99.5%
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> Biochemical Reagents > Nucleic Acids & Nucleotides & Derivatives > 5-Aza-2-Deoxycytidine
Product Information
| Name | 5-Aza-2'-deoxycytidine |
| CAS | 2353-33-5 |
| Molecular Formula | C8H12N4O4 |
| Molecular Weight | 228.21 |
| Storage | Store at 2-8℃，2 years |
| Appearance | White Powder |
| Purity | ≥99.5% |
| Solubility | 5mg/mL glacial acetic acid |
| Unit | Piece |
| Specification | 25mg |
Product introduction
5-aza-2 '-deoxycytidine, also known as decitabine or 5-aza-2' -deoxycytidine, is a natural 2' -deoxycytidine adenosine analogue. It inhibits the proliferation of tumor cells and prevents the occurrence of drug resistance by inhibiting DNA methyltransferase and reducing DNA methylation. It is the strongest DNA methylation-specific inhibitor known, belongs to S phase cell cycle specific drugs, and is suitable for the treatment of myelodysplastic syndrome (MDS). Hypomethylating agents can activate tumor suppressor genes and enhance the expression of regulatory genes such as differentiation genes in tumor cells, so they can achieve the purpose of treating MDS. After being phosphorylated, 5-aza-2 '-deoxycytidine (decitabine) exerts its antitumor effect. It acts directly on DNA and inhibits DNA methyltransferase, thereby hypomethylation of DNA and cell differentiation and death. Decitabine inhibits DNA methylation without affecting DNA synthesis in vitro. It can lead to demethylation of tumor cells and restore the normal function of genes, which is important for the control of cell differentiation and proliferation.
Precautions
This product is only used for research and experimental research.
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Related Paper
Experimental DNA Demethylation Reduces Expression Plasticity and Thermal Tolerance in Pacific Oysters
Click to check >>Author：Wang Xinxing, Cong Rihao, Li Ao, Wang Wei, Zhang Guofan, Li Li
IF：3.7270
Publish_to：MARINE BIOTECHNOLOGY
PMID：37079122
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