JC-10
Cat.No：J8050 Solarbio
Storage：Store at -20℃，avoid light and keep dry，1 year
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Name | JC-10 Mitochondrial Membrane Potential Fluorescent Probe |
| Molecular Weight | ~600 |
| Solubility | Soluble in DMSO |
| Ex/Em(nm/nm) | 510nm/525nm |
| Storage | Store at -20℃，avoid light and keep dry，1 year |
| Unit | Bottle |
| Specification | 1mg 5mg |
Product introduction:
JC-10 is a ideal fluorescent probe that is widely used for detecting mitochondrial membrane potential △Ψm. It can detect the membrane potential of cells, tissues, or purified mitochondria. When the mitochondrial membrane potential is high, JC-10 aggregates in the mitochondrial matrix, forming a polymer that can produce red fluorescence; When the mitochondrial membrane potential is low, JC-10 cannot aggregate in the mitochondrial matrix. At this time, JC-10 is a monomer that can produce green fluorescence. This makes it very convenient to detect changes in mitochondrial membrane potential through changes in fluorescence color. The relative ratio of red green fluorescence is commonly used to measure the depolarization of mitochondria.
The decrease in mitochondrial membrane potential is a landmark event in the early stages of cell apoptosis. The decrease in cell membrane potential can be easily detected through the transition of JC-10 from red fluorescence to green fluorescence, and the transition of JC-10 from red fluorescence to green fluorescence can also be used as a detection indicator for early cell apoptosis. The maximum excitation wavelength of JC-10 monomer is 515nm, and the maximum emission wavelength is 529nm; The maximum excitation wavelength of JC-10 polymer is 585nm, and the maximum emission wavelength is 590nm. During actual observation, conventional settings for observing red and green fluorescence are sufficient.
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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