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My CartReactivity：Rat,Mouse,Human
Application：IHC,IF,ELISA,WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：16173
Host：Rabbit
Qty：
Size：
| Name | Anti-IL18 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:500-2000. IHC 1:100-500. IF 1:100-500. ELISA 1:5000-10000. |
| Target | IL18 |
| Background | Pro-inflammatory cytokine primarily involved in epithelial barrier repair， polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:26638072， PubMed:26638073). Upon binding to IL18R1 and IL18RAP， forms a signaling ternary complex which activates NF-kappa-B， triggering synthesis of inflammatory mediators (By similarity). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956). |
| Swiss Prot | P70380 |
| Gene ID | 16173 |
| Subcellular Location | Secreted |
| Immunogen | A synthetic peptide of mouse IL18 |
| Public Immunogen Range | 51-120aa |
| Calculated MW | 22kDa |
| Observed MW | 18kDa |
| Purification Method | Affinity purification |
| Storage Buffer | 0.01M TBS (pH7.4) with 1% BSA， 0.02% Proclin300 and 50% Glycerol. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | 支 |
| Specification | 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | WB IHC IF ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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