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My CartReactivity：Rat,Mouse,Human
Application：IHC,WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：114548
Host：Rabbit
Qty：
Size：
| Name | Anti-NLRP3 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Cow;Monkey |
| Dilution Ratio | WB 1:1000-3000. IHC 1:50-200. |
| Target | NLRP3 |
| Background | This gene encodes a pyrin-like protein containing a pyrin domain， a nucleotide-binding site (NBS) domain， and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC， which contains a caspase recruitment domain， and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling， and it plays a role in the regulation of inflammation， the immune response， and apoptosis. The SARS-CoV 3a protein， a transmembrane pore-forming viroporin， has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS)， Muckle-Wells syndrome (MWS)， chronic infantile neurological cutaneous and articular (CINCA) syndrome， neonatal-onset multisystem inflammatory disease (NOMID)， keratoendotheliitis fugax hereditarian， and deafness， autosomal dominant 34， with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5‘ UTR structures are suggested by available data; however， insufficient evidence is available to determine if all of the represented 5‘ UTR splice patterns are biologically valid. |
| Swiss Prot | Q96P20 |
| Gene ID | 114548 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | A synthetic peptide of human NLRP3 |
| Public Immunogen Range | 1-51/1036aa |
| Calculated MW | 84/106/112/116/118kDa |
| Observed MW | 110kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | 支 |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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