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My CartStorage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
Appearance：Lyophilized powder
Gene ID：177
Application：Blocking Peptide of K115890P Antibody
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| Name | RAGE Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Swiss Prot | Q15109 |
| Gene ID | 177 |
| Background | Advanced glycosylation end product-specific receptor (AGER;RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation and are know as advanced glycation end products (AGEs).It is expressed by endothelium mononuclear phagocytes neurons and smooth muscle cells.Whereas RAGE is present at high levels during development especially in the central nervous system its levels decline during maturity.The increased expression of RAGE is associated with several pathological states such as diabetic vasculopathy neuropathy retinopathy and other disorders including Alzheimer's disease and immune/inflammatory reactions of the vessel walls.In diabetic tissues the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE.This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics.In the brain RAGE also binds amyloid beta (Ab).Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease this leads to the hyperstimulation of RAGE.The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration. |
| Application | Blocking Peptide of K115890P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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