Nocistatin
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Cat.No：CLP1195 Solarbio
CAS：207392-60-7
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 207392-60-7 |
| Sequence(1LC) | EQKQLQ |
| Sequence(3LC) | Glu-Gln-Lys-Gln-Leu-Gln |
| Molecular Formula | C32H56N10O12 |
| Molecular Weight | 772.85 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Opioid Peptides |
| Background | Nocistatin， a neuropeptide， is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a Gi/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia. |
| In Vitro | In the isolated organ bath studies Nocistatin (1 pM-1μM) inhibits the prostaglandin- and the KCl-evoked contractions in the uterus dose-dependently. Nocistatin， generated locally in the uterus， exerts an inhibitory effect， the mechanism being mediated in part by Ca2+-dependent K+ channels， the elevation of cAMP levels and sensory neuropeptides. |
| In Vivo | Intrathecal administration of Nocistatin (10 pg-1 μg) nociceptin or orphanin FQ (Noc/OFQ) induces pain responses including allodynia and hyperalgesia. Simultaneous administration of Nocistatin blocks the allodynia and hyperalgesia induced by Noc/OFQ. Nocistatin also attenuates the allodynia and hyperalgesia evoked by prostaglandin E2 and the inflammatory hyperalgesia induced by formalin or carrageenan/kaolin， and reversed the Noc/OFQ-induced inhibition of morphine analgesia at picogram doses. Nocistatin counteracted the impairment of learning and memory induced by Noc/OFQ or scopolamine. Nocistatin is widely present in the spinal cord and brain. Although Nocistatin does not bind to the Noc/OFQ receptor， it binds to the membrane of mouse brain and spinal cord with a high affinity. |
| Reference | [1]. Beáta H Deák， et al. Nocistatin inhibits pregnant rat uterine contractions in vitro: roles of calcitonin gene-related peptide and calcium-dependent potassium channel. Eur J Pharmacol. 2013 Aug 15;714(1-3):96-104. [2]. E Okuda-Ashitaka， et al. Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor. Peptides. 2000 Jul;21(7):1101-9. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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