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My CartCAS：182912-74-9
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| CAS | 182912-74-9 |
| Sequence(1LC) | LPFFD |
| Sequence(3LC) | Leu-Pro-Phe-Phe-Asp |
| Molecular Formula | C33H43N5O8 |
| Molecular Weight | 637.72 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Solubility | H2O：50 mg/mL; *Ultrasonic solubilization; |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Amyloid Peptides |
| Background | β-Sheet Breaker Peptide iAβ5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD)， due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus， β-Sheet Breaker Peptide iAβ5 prevents and/or reverses neuronal shrinkage caused by Abeta， and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 labeled by hydrophobic benzyl alcohol (HBA) tag， can be used for quantitative assay by showing vivid blue color under acidic conditions. |
| In Vitro | β-Sheet Breaker Peptide iAβ5 (1.5 μg/μL; 7 days) incubates with Aβ1-42 (0.5 μg/μL) for 7 days， inhibits amyloid βprotein fibrillogenesis， disassembles preformed fibrils in vitro and prevents neuronal death induced by fibrils in cell culture. β-Sheet Breaker Peptide iAβ5 (60 μM; 48 h) shows insignificant cytotoxicity in human neuroblastoma (IMR-32) cell treated with 50 μM aggregated Aβ1-42 for 2 days. |
| In Vivo | β-Sheet Breaker Peptide iAβ5 (100 nmol/rat; Intra-amygdala injection; 7 days) coinjected with Aβ1-42 (5 nmol) into in the rat amygdala， blocks Aβ1-42 neurotoxicity in tissue culture， and amyloid fibril formation in the rat model. β-Sheet Breaker Peptide iAβ5 (100 nmol/rat， 200 nmol/rat; Intra-amygdaloid injection; 7 days) followed by Aβ1-42 (5 nmol)， induces disassembly of pre-existing Aβ fibrils in vivo， and leads to a reversal or prevention of Aβ-induced histopathological changes in rat model. |
| Reference | [1]. Soto C， et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer’s therapy. Nat Med. 1998 Jul;4(7):822-6. [2]. Sigurdsson EM， et al. In vivo reversal of amyloid-beta lesions in rat brain. J Neuropathol Exp Neurol. 2000 Jan;59(1):11-7. [3]. Okada Y， et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Org Lett. 2015 Sep 4;17(17):4264-7. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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