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Amyloid 17-42

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Cat.No：CLP1485 Solarbio

CAS：155178-13-5

Purity：≥95%

Appearance：Lyophilized powder

Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)

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Product Information

Product Type	Peptides
CAS	155178-13-5
Sequence(1LC)	LVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence(3LC)	Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Molecular Formula	C119H194N28O33S1
Molecular Weight	2577.05
Purity	≥95%
Appearance	Lyophilized powder
Salt Form	Trifluoroacetate salt
Source	Synthetic
Storage	Store at -20℃，2 years.(Avoid freeze/thaw cycles)
Category/Label	Amyloid Peptides
Background	Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer’s disease and cerebellar pre-amyloid in Down’s syndrome， derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
In Vitro	Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells. Amyloid 17-42 (20 μM; 48 h， 72 h) activates caspase-8 and caspase-3， induced poly(ADP-ribose) polymerase cleavage. Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK). Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
Reference	[1]. Wanli Wei， et al. Abeta 17-42 in Alzheimer’s disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002 Sep;125(Pt 9):2036-43.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.

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