Melittin free acid
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Cat.No：CLP1245 Solarbio
CAS：123168-46-7
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 123168-46-7 |
| Sequence(1LC) | GIGAVLKVLTTGLPALISWIKRKRQQ |
| Sequence(3LC) | Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln |
| Molecular Formula | C131H228N38O32 |
| Molecular Weight | 2847.45 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Virus Related Peptides |
| Background | Melittin free acid is a basic 26-amino-acid polypeptide， the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis， repressing (1，3)-β-D-glucan synthase and participating in other pathways. |
| In Vitro | Melittin free acid stimulates the biosynthesis of prostaglandins by mouse transformed fibroblasts (MC5-5)， human fibroblasts (D550)， rabbit aorta endothelial cells (CLO)， rat lung type II alveolar pneumocytes (L-2) and rabbit smooth muscle cells (R-I). Melittin free acid stimulates the release of arachidonic acid from the cellular phospholipids of MC5-5 cells. Melittin free acid induces the accumulation of ROS in germinating conidia of A. flavus. Melittin free acid inhibits B. cinerea MUCL 30158 and CECT 2100 strains with IC50 values of 3.1 and 24 μM， respectively. |
| In Vivo | Melittin (intraperitoneal inoculation) increases 13，14-dihydro-15-keto-PGE2 levels in peripheral blood of mice. |
| Reference | [1]. Hassid A， Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. [2]. Memariani H， Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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