Myelopeptide-2
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Cat.No：CLP1770 Solarbio
CAS：137833-31-9
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 137833-31-9 |
| Sequence(1LC) | LVVYPW |
| Sequence(3LC) | Leu-Val-Val-Tyr-Pro-Trp |
| Molecular Formula | C41H57N7O8 |
| Molecular Weight | 775.93 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Other Peptides |
| Background | Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures， can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis， is perspective to be applied in antitumor and antivirus research. |
| In Vitro | Myelopeptide-2 (1 ng/mL-0.1 mg/mL; 72 h) restores phytohemagglutinin (PHA， 2.5 mg/mL)-induced proliferation of human peripheral blood T lymphocytes. Myelopeptide-2 (0.1 mg/mL and 1 mg/mL; 1-3 d) increases the level of the reduced IL-2 synthesis in human T lymphocytes damaged by HL-60 or measles virus. |
| In Vivo | Myelopeptide-2 (10 μg/kg; injection; for 20-50 weeks) delays the appearance of urethane-induced tumors and decreases the number of spontaneous and urethane-induced lung tumors in mice with short-term treatment. |
| Reference | [1]. Mikhailova AA， et al. Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus. J Immunother. 2006 May-Jun;29(3):306-12. [2]. Mikhailova AA， et al. Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice. Bull Exp Biol Med. 2002 Jan;133(1):68-70. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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