KLD-12
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Cat.No：CLP1756 Solarbio
CAS：800379-47-9
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 800379-47-9 |
| Sequence(1LC) | Ac-KLDLKLDLKLDL-NH2 |
| Sequence(3LC) | Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2 |
| Molecular Formula | C68H122N16O19 |
| Molecular Weight | 1467.79 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Other Peptides |
| Background | KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair. |
| In Vitro | KLD-12 forms self-assembled polypeptide with SDF-1， improves the survival of bone marrow stromal cells (BMSCs)， promotes osteogenic differentiation of BMSCs and cell migration through Wnt/β-catenin pathway. |
| In Vivo | KLD-12 (10-250 μg/rat， single dose， injection to infracture site) promotes bone regeneration at the fracture site in a dose-dependent manner in Sprague-Dawley rats model with drill-hole injury in femur. |
| Reference | [1]. Cao M， et al.， Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs?via?the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858.? [2]. Tripathi JK， et al.， Variants of self-assembling peptide， KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.? [3]. Kisiday J， Jet al.， Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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